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Structural basis of cytoplasmic Na_V1.5 and Na_V1.4 regulation

In Special Collection:

Biophysics 2021

Sara Nathan, Sandra B. Gabelli, Jesse B. Yoder, Lakshmi Srinivasan, Richard W. Aldrich, Gordon F. Tomaselli, Manu Ben-Johny, L. Mario Amzel

J Gen Physiol (2020) 153 (1): e202012722.

DOI: https://doi.org/10.1085/jgp.202012722

Published: 11 December 2020

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Journal Articles

Influences: Growing up in Yale Physiology

Richard W. Aldrich

J Gen Physiol (2018) 150 (2): 177–179.

DOI: https://doi.org/10.1085/jgp.201711990

Published: 23 January 2018

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Journal Articles

Structural identifiability of equilibrium ligand-binding parameters

Thomas R. Middendorf, Richard W. Aldrich

J Gen Physiol (2016) 149 (1): 105–119.

DOI: https://doi.org/10.1085/jgp.201611702

Published: 19 December 2016

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Journal Articles

The structure of binding curves and practical identifiability of equilibrium ligand-binding parameters

Thomas R. Middendorf, Richard W. Aldrich

J Gen Physiol (2016) 149 (1): 121–147.

DOI: https://doi.org/10.1085/jgp.201611703

Published: 19 December 2016

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Journal Articles

A new standard: A review of Handbook of Ion Channels

Richard W. Aldrich

J Gen Physiol (2015) 146 (2): 119–121.

DOI: https://doi.org/10.1085/jgp.201511461

Published: 27 July 2015

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Journal Articles

Determination of parameter identifiability in nonlinear biophysical models: A Bayesian approach

Keegan E. Hines, Thomas R. Middendorf, Richard W. Aldrich

J Gen Physiol (2014) 143 (3): 401–416.

DOI: https://doi.org/10.1085/jgp.201311116

Published: 10 February 2014

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Journal Articles

Calcium-dependent stoichiometries of the KCa_2.2 (SK) intracellular domain/calmodulin complex in solution

D. Brent Halling, Sophia A. Kenrick, Austen F. Riggs, Richard W. Aldrich

J Gen Physiol (2014) 143 (2): 231–252.

DOI: https://doi.org/10.1085/jgp.201311007

Published: 13 January 2014

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Journal Articles

Charge substitution for a deep-pore residue reveals structural dynamics during BK channel gating

Xixi Chen, Richard W. Aldrich

J Gen Physiol (2011) 138 (2): 137–154.

DOI: https://doi.org/10.1085/jgp.201110632

Published: 11 July 2011

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Includes: Supplementary data

Journal Articles

EF hands at the N-lobe of calmodulin are required for both SK channel gating and stable SK–calmodulin interaction

Weiyan Li, David B. Halling, Amelia W. Hall, Richard W. Aldrich

J Gen Physiol (2009) 134 (4): 281–293.

DOI: https://doi.org/10.1085/jgp.200910295

Published: 14 September 2009

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Journal Articles

State-dependent Block of BK Channels by Synthesized Shaker Ball Peptides

Weiyan Li, Richard W. Aldrich

J Gen Physiol (2006) 128 (4): 423–441.

DOI: https://doi.org/10.1085/jgp.200609521

Published: 11 September 2006

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Journal Articles

State-independent Block of BK Channels by an Intracellular Quaternary Ammonium

Christina M. Wilkens, Richard W. Aldrich

J Gen Physiol (2006) 128 (3): 347–364.

DOI: https://doi.org/10.1085/jgp.200609579

Published: 28 August 2006

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Journal Articles

Binding of a Gating Modifier Toxin Induces Intersubunit Cooperativity Early in the Shaker K Channel's Activation Pathway

Jon T. Sack, Richard W. Aldrich

J Gen Physiol (2006) 128 (1): 119–132.

DOI: https://doi.org/10.1085/jgp.200609492

Published: 26 June 2006

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Journal Articles

Statistical Limits to the Identification of Ion Channel Domains by Sequence Similarity

Anthony A. Fodor, Richard W. Aldrich

J Gen Physiol (2006) 127 (6): 755–766.

DOI: https://doi.org/10.1085/jgp.200509419

Published: 30 May 2006

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Includes: Supplementary data

Journal Articles

Relationship between Pore Occupancy and Gating in BK Potassium Channels

Rebecca A. Piskorowski, Richard W. Aldrich

J Gen Physiol (2006) 127 (5): 557–576.

DOI: https://doi.org/10.1085/jgp.200509482

Published: 24 April 2006

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Journal Articles

Unique Inner Pore Properties of BK Channels Revealed by Quaternary Ammonium Block

Weiyan Li, Richard W. Aldrich

J Gen Physiol (2004) 124 (1): 43–57.

DOI: https://doi.org/10.1085/jgp.200409067

Published: 14 June 2004

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Journal Articles

A Gastropod Toxin Selectively Slows Early Transitions in the Shaker K Channel's Activation Pathway

Jon T. Sack, Richard W. Aldrich, William F. Gilly

J Gen Physiol (2004) 123 (6): 685–696.

DOI: https://doi.org/10.1085/jgp.200409047

Published: 17 May 2004

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Journal Articles

Coupling between Voltage Sensor Activation, Ca²⁺ Binding and Channel Opening in Large Conductance (BK) Potassium Channels

Frank T. Horrigan, Richard W. Aldrich

J Gen Physiol (2002) 120 (3): 267–305.

DOI: https://doi.org/10.1085/jgp.20028605

Published: 26 August 2002

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Journal Articles

Modification of Cyclic Nucleotide–Gated Ion Channels by Ultraviolet Light

Thomas R. Middendorf, Richard W. Aldrich, Denis A. Baylor

J Gen Physiol (2000) 116 (2): 227–252.

DOI: https://doi.org/10.1085/jgp.116.2.227

Published: 31 July 2000

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Journal Articles

Effects of Ultraviolet Modification on the Gating Energetics of Cyclic Nucleotide–Gated Channels

Thomas R. Middendorf, Richard W. Aldrich

J Gen Physiol (2000) 116 (2): 253–282.

DOI: https://doi.org/10.1085/jgp.116.2.253

Published: 31 July 2000

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Journal Articles

Determinants of Voltage-Dependent Gating and Open-State Stability in the S5 Segment of Shaker Potassium Channels

Max Kanevsky, Richard W. Aldrich

J Gen Physiol (1999) 114 (2): 215–242.

DOI: https://doi.org/10.1085/jgp.114.2.215

Published: 01 August 1999

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NARROW

Structural basis of cytoplasmic Na_V1.5 and Na_V1.4 regulation

Influences: Growing up in Yale Physiology

Structural identifiability of equilibrium ligand-binding parameters

The structure of binding curves and practical identifiability of equilibrium ligand-binding parameters

A new standard: A review of Handbook of Ion Channels

Determination of parameter identifiability in nonlinear biophysical models: A Bayesian approach

Calcium-dependent stoichiometries of the KCa_2.2 (SK) intracellular domain/calmodulin complex in solution

Charge substitution for a deep-pore residue reveals structural dynamics during BK channel gating

EF hands at the N-lobe of calmodulin are required for both SK channel gating and stable SK–calmodulin interaction

State-dependent Block of BK Channels by Synthesized Shaker Ball Peptides

State-independent Block of BK Channels by an Intracellular Quaternary Ammonium

Binding of a Gating Modifier Toxin Induces Intersubunit Cooperativity Early in the Shaker K Channel's Activation Pathway

Statistical Limits to the Identification of Ion Channel Domains by Sequence Similarity

Relationship between Pore Occupancy and Gating in BK Potassium Channels

Unique Inner Pore Properties of BK Channels Revealed by Quaternary Ammonium Block

A Gastropod Toxin Selectively Slows Early Transitions in the Shaker K Channel's Activation Pathway

Coupling between Voltage Sensor Activation, Ca²⁺ Binding and Channel Opening in Large Conductance (BK) Potassium Channels

Modification of Cyclic Nucleotide–Gated Ion Channels by Ultraviolet Light

Effects of Ultraviolet Modification on the Gating Energetics of Cyclic Nucleotide–Gated Channels

Determinants of Voltage-Dependent Gating and Open-State Stability in the S5 Segment of Shaker Potassium Channels

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