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Optimization of CFTR gating through the evolution of its extracellular loops

Márton A. Simon, László Csanády

J Gen Physiol (2023) 155 (4): e202213264.

DOI: https://doi.org/10.1085/jgp.202213264

Published: 01 February 2023

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Journal Articles

RLC phosphorylation amplifies Ca²⁺ sensitivity of force in myocardium from cMyBP-C knockout mice

Kyrah L. Turner, Haley S. Morris, Peter O. Awinda, Daniel P. Fitzsimons, Bertrand C.W. Tanner

J Gen Physiol (2023) 155 (4): e202213250.

DOI: https://doi.org/10.1085/jgp.202213250

Published: 30 January 2023

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Includes: Supplementary data

Journal Articles

Microscopic mechanism of PIEZO1 activation by pressure-induced membrane stretch

Tharaka D. Wijerathne, Alper D. Ozkan, Jérôme J. Lacroix

J Gen Physiol (2023) 155 (5): e202213260.

DOI: https://doi.org/10.1085/jgp.202213260

Published: 30 January 2023

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Cardiomyocyte sarcomere length variability: Membrane fluorescence versus second harmonic generation myosin imaging

Oleg Lookin, Pieter de Tombe, Najlae Boulali, Csilla Gergely, Thierry Cloitre, Olivier Cazorla

J Gen Physiol (2023) 155 (4): e202213289.

DOI: https://doi.org/10.1085/jgp.202213289

Published: 25 January 2023

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Journal Articles

Real-time observation of functional specialization among phosphorylation sites in CFTR

Daniel T. Infield, Miranda E. Schene, Frederico S. Fazan, Grace D. Galles, Jason D. Galpin, Christopher A. Ahern

J Gen Physiol (2023) 155 (4): e202213216.

DOI: https://doi.org/10.1085/jgp.202213216

Published: 25 January 2023

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Includes: Supplementary data

Journal Articles

Mechanosensitive membrane proteins: Usual and unusual suspects in mediating mechanotransduction

Miriam B. Goodman, Elizabeth S. Haswell, Valeria Vásquez

J Gen Physiol (2023) 155 (3): e202213248.

DOI: https://doi.org/10.1085/jgp.202213248

Published: 25 January 2023

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Journal Articles

Charge-voltage curves of Shaker potassium channel are not hysteretic at steady state

John Cowgill, Baron Chanda

J Gen Physiol (2023) 155 (3): e202112883.

DOI: https://doi.org/10.1085/jgp.202112883

Published: 24 January 2023

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Journal Articles

Sarcomere length affects Ca²⁺ sensitivity of contraction in ischemic but not non-ischemic myocardium

Bertrand C.W. Tanner, Peter O. Awinda, Keinan B. Agonias, Seetharamaiah Attili, Cheavar A. Blair, Mindy S. Thompson, Lori A. Walker, Thomas Kampourakis, Kenneth S. Campbell

J Gen Physiol (2023) 155 (3): e202213200.

DOI: https://doi.org/10.1085/jgp.202213200

Published: 12 January 2023

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Includes: Supplementary data

Journal Articles

Cooperativity of myosin II motors in the non-regulated and regulated thin filaments investigated with high-speed AFM

Oleg S. Matusovsky, Alf Månsson, Dilson E. Rassier

J Gen Physiol (2023) 155 (3): e202213190.

DOI: https://doi.org/10.1085/jgp.202213190

Published: 12 January 2023

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Includes: Supplementary data

Journal Articles

Conformational changes linked to ADP release from human cardiac myosin bound to actin-tropomyosin

Matthew H. Doran, Michael J. Rynkiewicz, David Rassici, Skylar M.L. Bodt, Meaghan E. Barry, Esther Bullitt, Christopher M. Yengo, Jeffrey R. Moore, William Lehman

J Gen Physiol (2023) 155 (3): e202213267.

DOI: https://doi.org/10.1085/jgp.202213267

Published: 12 January 2023

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Journal Articles

Fluorescence lifetime-based assay reports structural changes in cardiac muscle mediated by effectors of contractile regulation

Alexey V. Dvornikov, Thomas A. Bunch, Victoria C. Lepak, Brett A. Colson

J Gen Physiol (2023) 155 (3): e202113054.

DOI: https://doi.org/10.1085/jgp.202113054

Published: 12 January 2023

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Includes: Supplementary data

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Multiscale molecular dynamics simulations predict arachidonic acid binding sites in human ASIC1a and ASIC3 transmembrane domains

Anna Ananchenko, Maria Musgaard

J Gen Physiol (2023) 155 (3): e202213259.

DOI: https://doi.org/10.1085/jgp.202213259

Published: 10 January 2023

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Journal Articles

Gating and modulation of an inward-rectifier potassium channel

In Special Collection:

Biophysics 2023

Vishwanath Jogini, Morten Ø. Jensen, David E. Shaw

J Gen Physiol (2022) 155 (2): e202213085.

DOI: https://doi.org/10.1085/jgp.202213085

Published: 16 December 2022

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Includes: Supplementary data

Journal Articles

An α–π transition in S6 shapes the conformational cycle of the bacterial sodium channel NavAb

Koushik Choudhury, Rebecca J. Howard, Lucie Delemotte

J Gen Physiol (2022) 155 (2): e202213214.

DOI: https://doi.org/10.1085/jgp.202213214

Published: 14 December 2022

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Journal Articles

Mechanistic insights on K_ATP channel regulation from cryo-EM structures

Camden M. Driggers, Show-Ling Shyng

J Gen Physiol (2022) 155 (1): e202113046.

DOI: https://doi.org/10.1085/jgp.202113046

Published: 28 November 2022

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Journal Articles

Full opening of helix bundle crossing does not lead to NaK channel activation

In Special Collection:

Biophysics 2023

Vilius Kurauskas, Marco Tonelli, Katherine Henzler-Wildman

J Gen Physiol (2022) 154 (12): e202213196.

DOI: https://doi.org/10.1085/jgp.202213196

Published: 03 November 2022

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Includes: Supplementary data

Journal Articles

Molecular mechanism of claudin-15 strand flexibility: A computational study

Shadi Fuladi, Sarah McGuinness, Le Shen, Christopher R. Weber, Fatemeh Khalili-Araghi

J Gen Physiol (2022) 154 (12): e202213116.

DOI: https://doi.org/10.1085/jgp.202213116

Published: 01 November 2022

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Journal Articles

Cardiac myosin filaments are directly regulated by calcium

In Special Collection:

Biophysics 2023

Weikang Ma, Suman Nag, Henry Gong, Lin Qi, Thomas C. Irving

J Gen Physiol (2022) 154 (12): e202213213.

DOI: https://doi.org/10.1085/jgp.202213213

Published: 01 November 2022

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Includes: Supplementary data

Journal Articles

The funny current I_f is essential for the fight-or-flight response in cardiac pacemaker cells

In Special Collection:

Biophysics 2023

Colin H. Peters, Christian Rickert, Stefano Morotti, Eleonora Grandi, Kurt A. Aronow, Kurt G. Beam, Catherine Proenza

J Gen Physiol (2022) 154 (12): e202213193.

DOI: https://doi.org/10.1085/jgp.202213193

Published: 28 October 2022

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Includes: Supplementary data

Journal Articles

A Cantú syndrome mutation produces dual effects on K_ATP channels by disrupting ankyrin B regulation

Teresa Crespo-García, Marcos Rubio-Alarcón, Anabel Cámara-Checa, María Dago, Josu Rapún, Paloma Nieto-Marín, María Marín, Jorge Cebrián, Juan Tamargo, Eva Delpón, Ricardo Caballero

J Gen Physiol (2022) 155 (1): e202112995.

DOI: https://doi.org/10.1085/jgp.202112995

Published: 26 October 2022

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Includes: Supplementary data

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Optimization of CFTR gating through the evolution of its extracellular loops

RLC phosphorylation amplifies Ca²⁺ sensitivity of force in myocardium from cMyBP-C knockout mice

Microscopic mechanism of PIEZO1 activation by pressure-induced membrane stretch

Cardiomyocyte sarcomere length variability: Membrane fluorescence versus second harmonic generation myosin imaging

Real-time observation of functional specialization among phosphorylation sites in CFTR

Mechanosensitive membrane proteins: Usual and unusual suspects in mediating mechanotransduction

Charge-voltage curves of Shaker potassium channel are not hysteretic at steady state

Sarcomere length affects Ca²⁺ sensitivity of contraction in ischemic but not non-ischemic myocardium

Cooperativity of myosin II motors in the non-regulated and regulated thin filaments investigated with high-speed AFM

Conformational changes linked to ADP release from human cardiac myosin bound to actin-tropomyosin

Fluorescence lifetime-based assay reports structural changes in cardiac muscle mediated by effectors of contractile regulation

Multiscale molecular dynamics simulations predict arachidonic acid binding sites in human ASIC1a and ASIC3 transmembrane domains

Gating and modulation of an inward-rectifier potassium channel

An α–π transition in S6 shapes the conformational cycle of the bacterial sodium channel NavAb

Mechanistic insights on K_ATP channel regulation from cryo-EM structures

Full opening of helix bundle crossing does not lead to NaK channel activation

Molecular mechanism of claudin-15 strand flexibility: A computational study

Cardiac myosin filaments are directly regulated by calcium

The funny current I_f is essential for the fight-or-flight response in cardiac pacemaker cells

A Cantú syndrome mutation produces dual effects on K_ATP channels by disrupting ankyrin B regulation

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