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Journal Articles

Mechanisms of dihydropyridine agonists and antagonists in view of cryo-EM structures of calcium and sodium channels

Denis B. Tikhonov, Boris S. Zhorov

J Gen Physiol (2023) 155 (11): e202313418.

https://doi.org/10.1085/jgp.202313418

Published: 20 September 2023

View article titled, Mechanisms of dihydropyridine agonists and antagonists in view of cryo-EM structures of calcium and sodium channels

Journal Articles

Mitochondrial morphology governs ATP production rate

Guadalupe C. Garcia, Kavya Gupta, Thomas M. Bartol, Terrence J. Sejnowski, Padmini Rangamani

J Gen Physiol (2023) 155 (9): e202213263.

https://doi.org/10.1085/jgp.202213263

Published: 24 August 2023

View article titled, Mitochondrial morphology governs ATP production rate

Journal Articles

Alkali metal cations modulate the geometry of different binding sites in HCN4 selectivity filter for permeation or block

Jan H. Krumbach, Daniel Bauer, Atiyeh Sadat Sharifzadeh, Andrea Saponaro, Rene Lautenschläger, Kristina Lange, Oliver Rauh, Dario DiFrancesco, Anna Moroni, Gerhard Thiel, Kay Hamacher

J Gen Physiol (2023) 155 (10): e202313364.

https://doi.org/10.1085/jgp.202313364

Published: 31 July 2023

View article titled, Alkali metal cations modulate the geometry of different binding sites in HCN4 selectivity filter for permeation or block

Includes: Supplementary data

Journal Articles

Sodium channel subpopulations with distinct biophysical properties and subcellular localization enhance cardiac conduction

Seth H. Weinberg

J Gen Physiol (2023) 155 (8): e202313382.

https://doi.org/10.1085/jgp.202313382

Published: 07 June 2023

View article titled, Sodium channel subpopulations with distinct biophysical properties and subcellular localization enhance cardiac conduction

Journal Articles

Machine learning meets Monte Carlo methods for models of muscle’s molecular machinery to classify mutations

Anthony Asencio, Sage Malingen, Kristina B. Kooiker, Joseph D. Powers, Jennifer Davis, Thomas Daniel, Farid Moussavi-Harami

J Gen Physiol (2023) 155 (5): e202213291.

https://doi.org/10.1085/jgp.202213291

Published: 31 March 2023

View article titled, Machine learning meets Monte Carlo methods for models of muscle’s molecular machinery to classify mutations

Journal Articles

A cooperative knock-on mechanism underpins Ca²⁺-selective cation permeation in TRPV channels

In Special Collection:

Physiology of Pain Detection and Processing Collection 2023

Callum M. Ives, Neil J. Thomson, Ulrich Zachariae

J Gen Physiol (2023) 155 (5): e202213226.

https://doi.org/10.1085/jgp.202213226

Published: 21 March 2023

View article titled, A cooperative knock-on mechanism underpins Ca2+-selective cation permeation in TRPV channels

Includes: Supplementary data

Journal Articles

Multiscale molecular dynamics simulations predict arachidonic acid binding sites in human ASIC1a and ASIC3 transmembrane domains

Anna Ananchenko, Maria Musgaard

J Gen Physiol (2023) 155 (3): e202213259.

https://doi.org/10.1085/jgp.202213259

Published: 10 January 2023

View article titled, Multiscale molecular dynamics simulations predict arachidonic acid binding sites in human ASIC1a and ASIC3 transmembrane domains

Journal Articles

Gating and modulation of an inward-rectifier potassium channel

In Special Collection:

Biophysics 2023

Vishwanath Jogini, Morten Ø. Jensen, David E. Shaw

J Gen Physiol (2022) 155 (2): e202213085.

https://doi.org/10.1085/jgp.202213085

Published: 16 December 2022

View article titled, Gating and modulation of an inward-rectifier potassium channel

Includes: Supplementary data

Journal Articles

When is a hydrophobic gate not a hydrophobic gate?

David Seiferth, Philip C. Biggin, Stephen J. Tucker

J Gen Physiol (2022) 154 (11): e202213210.

https://doi.org/10.1085/jgp.202213210

Published: 26 October 2022

View article titled, When is a hydrophobic gate not a hydrophobic gate?

Journal Articles

Disorder in Ca²⁺ release unit locations confers robustness but cuts flexibility of heart pacemaking Ca²⁺ release propagation controls heart pacemaking

Anna V. Maltsev, Michael D. Stern, Victor A. Maltsev

J Gen Physiol (2022) 154 (9): e202113061.

https://doi.org/10.1085/jgp.202113061

Published: 09 August 2022

View article titled, Disorder in Ca2+ release unit locations confers robustness but cuts flexibility of heart pacemaking Ca2+ release propagation controls heart pacemaking

Includes: Supplementary data

Journal Articles

Closed-state inactivation of cardiac, skeletal, and neuronal sodium channels is isoform specific

Niklas Brake, Adamo S. Mancino, Yuhao Yan, Takushi Shimomura, Yoshihiro Kubo, Anmar Khadra, Derek Bowie

J Gen Physiol (2022) 154 (7): e202112921.

https://doi.org/10.1085/jgp.202112921

Published: 25 May 2022

View article titled, Closed-state inactivation of cardiac, skeletal, and neuronal sodium channels is isoform specific

Includes: Supplementary data

Journal Articles

A strategy for determining the equilibrium constants for heteromeric ion channels in a complex model

Klaus Benndorf, Thomas Eick, Christian Sattler, Ralf Schmauder, Eckhard Schulz

J Gen Physiol (2022) 154 (6): e202113041.

https://doi.org/10.1085/jgp.202113041

Published: 29 April 2022

View article titled, A strategy for determining the equilibrium constants for heteromeric ion channels in a complex model

Includes: Supplementary data

Journal Articles

A mathematical model to quantify RYR Ca²⁺ leak and associated heat production in resting human skeletal muscle fibers

Christopher J. Barclay, Bradley S. Launikonis

J Gen Physiol (2022) 154 (9): e202112994.

https://doi.org/10.1085/jgp.202112994

Published: 21 March 2022

View article titled, A mathematical model to quantify RYR Ca2+ leak and associated heat production in resting human skeletal muscle fibers

Journal Articles

Spliced isoforms of the cardiac Nav1.5 channel modify channel activation by distinct structural mechanisms

Adamo S. Mancino, William G. Glass, Yuhao Yan, Philip C. Biggin, Derek Bowie

J Gen Physiol (2022) 154 (5): e202112906.

https://doi.org/10.1085/jgp.202112906

Published: 17 March 2022

View article titled, Spliced isoforms of the cardiac Nav1.5 channel modify channel activation by distinct structural mechanisms

Journal Articles

A flexible GAS belt responds to pore mutations changing the ion selectivity of proton-gated channels

Zhuyuan Chen, Sheng Lin, Tianze Xie, Jin-Ming Lin, Cecilia M. Canessa

J Gen Physiol (2021) 154 (1): e202112978.

https://doi.org/10.1085/jgp.202112978

Published: 12 November 2021

View article titled, A flexible GAS belt responds to pore mutations changing the ion selectivity of proton-gated channels

Includes: Supplementary data

Journal Articles

The Donnan-dominated resting state of skeletal muscle fibers contributes to resilience and longevity in dystrophic fibers

Catherine E. Morris, Joshua J. Wheeler, Béla Joos

J Gen Physiol (2021) 154 (1): e202112914.

https://doi.org/10.1085/jgp.202112914

Published: 03 November 2021

View article titled, The Donnan-dominated resting state of skeletal muscle fibers contributes to resilience and longevity in dystrophic fibers

Includes: Supplementary data

Journal Articles

Loss of crossbridge inhibition drives pathological cardiac hypertrophy in patients harboring the TPM1 E192K mutation

Lorenzo R. Sewanan, Jinkyu Park, Michael J. Rynkiewicz, Alice W. Racca, Nikolaos Papoutsidakis, Jonas Schwan, Daniel L. Jacoby, Jeffrey R. Moore, William Lehman, Yibing Qyang, Stuart G. Campbell

J Gen Physiol (2021) 153 (9): e202012640.

https://doi.org/10.1085/jgp.202012640

Published: 28 July 2021

View article titled, Loss of crossbridge inhibition drives pathological cardiac hypertrophy in patients harboring the TPM1 E192K mutation

Journal Articles

Intercalated disk nanoscale structure regulates cardiac conduction

In Special Collection:

Ion Channels Update 2022

Nicolae Moise, Heather L. Struckman, Celine Dagher, Rengasayee Veeraraghavan, Seth H. Weinberg

J Gen Physiol (2021) 153 (8): e202112897.

https://doi.org/10.1085/jgp.202112897

Published: 15 July 2021

View article titled, Intercalated disk nanoscale structure regulates cardiac conduction

Includes: Supplementary data

Journal Articles

ENaC and ROMK channels in the connecting tubule regulate renal K⁺ secretion

In Special Collection:

Ion Channels Update 2022

Lei Yang, Yuanyuan Xu, Diego Gravotta, Gustavo Frindt, Alan M. Weinstein, Lawrence G. Palmer

J Gen Physiol (2021) 153 (8): e202112902.

https://doi.org/10.1085/jgp.202112902

Published: 18 June 2021

View article titled, ENaC and ROMK channels in the connecting tubule regulate renal K+ secretion

Journal Articles

An arginine residue in the outer segment of hASIC1a TM1 affects both proton affinity and channel desensitization

In Special Collection:

Biophysics 2022 , Protons and Membrane Function

Zhuyuan Chen, Georg Kuenze, Jens Meiler, Cecilia M. Canessa

J Gen Physiol (2021) 153 (5): e202012802.

https://doi.org/10.1085/jgp.202012802

Published: 14 April 2021

View article titled, An arginine residue in the outer segment of hASIC1a TM1 affects both proton affinity and channel desensitization

NARROW

Mechanisms of dihydropyridine agonists and antagonists in view of cryo-EM structures of calcium and sodium channels

Mitochondrial morphology governs ATP production rate

Alkali metal cations modulate the geometry of different binding sites in HCN4 selectivity filter for permeation or block

Sodium channel subpopulations with distinct biophysical properties and subcellular localization enhance cardiac conduction

Machine learning meets Monte Carlo methods for models of muscle’s molecular machinery to classify mutations

A cooperative knock-on mechanism underpins Ca²⁺-selective cation permeation in TRPV channels

Multiscale molecular dynamics simulations predict arachidonic acid binding sites in human ASIC1a and ASIC3 transmembrane domains

Gating and modulation of an inward-rectifier potassium channel

When is a hydrophobic gate not a hydrophobic gate?

Disorder in Ca²⁺ release unit locations confers robustness but cuts flexibility of heart pacemaking Ca²⁺ release propagation controls heart pacemaking

Closed-state inactivation of cardiac, skeletal, and neuronal sodium channels is isoform specific

A strategy for determining the equilibrium constants for heteromeric ion channels in a complex model

A mathematical model to quantify RYR Ca²⁺ leak and associated heat production in resting human skeletal muscle fibers

Spliced isoforms of the cardiac Nav1.5 channel modify channel activation by distinct structural mechanisms

A flexible GAS belt responds to pore mutations changing the ion selectivity of proton-gated channels

The Donnan-dominated resting state of skeletal muscle fibers contributes to resilience and longevity in dystrophic fibers

Loss of crossbridge inhibition drives pathological cardiac hypertrophy in patients harboring the TPM1 E192K mutation

Intercalated disk nanoscale structure regulates cardiac conduction

ENaC and ROMK channels in the connecting tubule regulate renal K⁺ secretion

An arginine residue in the outer segment of hASIC1a TM1 affects both proton affinity and channel desensitization

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