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Journal Articles

A cooperative knock-on mechanism underpins Ca²⁺-selective cation permeation in TRPV channels

Callum M. Ives, Neil J. Thomson, Ulrich Zachariae

J Gen Physiol (2023) 155 (5): e202213226.

DOI: https://doi.org/10.1085/jgp.202213226

Published: 21 March 2023

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Includes: Supplementary data

Journal Articles

Probenecid affects muscle Ca²⁺ homeostasis and contraction independently from pannexin channel block

Francisco Jaque-Fernandez, Bruno Allard, Laloé Monteiro, Aude Lafoux, Corinne Huchet, Enrique Jaimovich, Christine Berthier, Vincent Jacquemond

J Gen Physiol (2023) 155 (4): e202213203.

DOI: https://doi.org/10.1085/jgp.202213203

Published: 23 February 2023

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Journal Articles

Segregation of Ca²⁺ signaling in olfactory signal transduction

Hiroko Takeuchi, Takashi Kurahashi

J Gen Physiol (2023) 155 (4): e202213165.

DOI: https://doi.org/10.1085/jgp.202213165

Published: 14 February 2023

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Journal Articles

Optimization of CFTR gating through the evolution of its extracellular loops

Márton A. Simon, László Csanády

J Gen Physiol (2023) 155 (4): e202213264.

DOI: https://doi.org/10.1085/jgp.202213264

Published: 01 February 2023

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Journal Articles

Myosin-binding protein C stabilizes, but is not the sole determinant of SRX myosin in cardiac muscle

Shane Nelson, Samantha Beck-Previs, Sakthivel Sadayappan, Carl Tong, David M. Warshaw

J Gen Physiol (2023) 155 (4): e202213276.

DOI: https://doi.org/10.1085/jgp.202213276

Published: 23 January 2023

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Includes: Supplementary data

Journal Articles

Sarcomere length affects Ca²⁺ sensitivity of contraction in ischemic but not non-ischemic myocardium

Bertrand C.W. Tanner, Peter O. Awinda, Keinan B. Agonias, Seetharamaiah Attili, Cheavar A. Blair, Mindy S. Thompson, Lori A. Walker, Thomas Kampourakis, Kenneth S. Campbell

J Gen Physiol (2023) 155 (3): e202213200.

DOI: https://doi.org/10.1085/jgp.202213200

Published: 12 January 2023

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Journal Articles

Role of ryanodine receptor 2 and FK506-binding protein 12.6 dissociation in pulmonary hypertension

Yong-Xiao Wang, Jorge Reyes-García, Annarita Di Mise, Yun-Min Zheng

J Gen Physiol (2023) 155 (3): e202213100.

DOI: https://doi.org/10.1085/jgp.202213100

Published: 10 January 2023

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Journal Articles

Myosin loop-4 is critical for optimal tropomyosin repositioning on actin during muscle activation and relaxation

Matthew H. Doran, Michael J. Rynkiewicz, Elumalai Pavadai, Skylar M.L. Bodt, David Rasicci, Jeffrey R. Moore, Christopher M. Yengo, Esther Bullitt, William Lehman

J Gen Physiol (2022) 155 (2): e202213274.

DOI: https://doi.org/10.1085/jgp.202213274

Published: 02 December 2022

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Includes: Supplementary data

Journal Articles

Ion channel regulation of gut immunity

Jing Feng, Zili Xie, Hongzhen Hu

J Gen Physiol (2022) 155 (2): e202113042.

DOI: https://doi.org/10.1085/jgp.202113042

Published: 02 December 2022

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Journal Articles

Single-molecule imaging reveals how mavacamten and PKA modulate ATP turnover in skeletal muscle myofibrils

Matvey Pilagov, Laurens W.H.J. Heling, Jonathan Walklate, Michael A. Geeves, Neil M. Kad

J Gen Physiol (2022) 155 (1): e202213087.

DOI: https://doi.org/10.1085/jgp.202213087

Published: 17 November 2022

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Includes: Supplementary data

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Cardiac myosin filaments are directly regulated by calcium

In Special Collection:

Biophysics 2023

Weikang Ma, Suman Nag, Henry Gong, Lin Qi, Thomas C. Irving

J Gen Physiol (2022) 154 (12): e202213213.

DOI: https://doi.org/10.1085/jgp.202213213

Published: 01 November 2022

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Includes: Supplementary data

Journal Articles

The funny current I_f is essential for the fight-or-flight response in cardiac pacemaker cells

In Special Collection:

Biophysics 2023

Colin H. Peters, Christian Rickert, Stefano Morotti, Eleonora Grandi, Kurt A. Aronow, Kurt G. Beam, Catherine Proenza

J Gen Physiol (2022) 154 (12): e202213193.

DOI: https://doi.org/10.1085/jgp.202213193

Published: 28 October 2022

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Journal Articles

Ca_V1.2 channelopathic mutations evoke diverse pathophysiological mechanisms

In Special Collection:

Biophysics 2023

Moradeke A. Bamgboye, Kevin G. Herold, Daiana C.O. Vieira, Maria K. Traficante, Philippa J. Rogers, Manu Ben-Johny, Ivy E. Dick

J Gen Physiol (2022) 154 (11): e202213209.

DOI: https://doi.org/10.1085/jgp.202213209

Published: 27 September 2022

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Includes: Supplementary data

Journal Articles

Molecular-level evidence of force maintenance by smooth muscle myosin during LC₂₀ dephosphorylation

Megan Jean Hammell, Linda Kachmar, Zsombor Balassy, Gijs IJpma, Anne-Marie Lauzon

J Gen Physiol (2022) 154 (10): e202213117.

DOI: https://doi.org/10.1085/jgp.202213117

Published: 24 August 2022

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Journal Articles

Postdevelopmental knockout of Orai1 improves muscle pathology in a mouse model of Duchenne muscular dystrophy

Maricela García-Castañeda, Antonio Michelucci, Nan Zhao, Sundeep Malik, Robert T. Dirksen

J Gen Physiol (2022) 154 (9): e202213081.

DOI: https://doi.org/10.1085/jgp.202213081

Published: 08 August 2022

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Includes: Supplementary data

Journal Articles

Expression of ENaC subunits in epithelia

Gustavo Frindt, Joel R. Meyerson, Alexandra Satty, Joseph M. Scandura, Lawrence G. Palmer

J Gen Physiol (2022) 154 (10): e202213124.

DOI: https://doi.org/10.1085/jgp.202213124

Published: 08 August 2022

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Includes: Supplementary data

Journal Articles

A novel method for determining murine skeletal muscle fiber type using autofluorescence lifetimes

Carlo Manno, Eshwar Tammineni, Lourdes Figueroa, Yuriana Oropeza-Almazán, Eduardo Rios

J Gen Physiol (2022) 154 (9): e202213143.

DOI: https://doi.org/10.1085/jgp.202213143

Published: 07 July 2022

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Journal Articles

How does flecainide impact RyR2 channel function?

Samantha C. Salvage, Christopher L.-H. Huang, James A. Fraser, Angela F. Dulhunty

J Gen Physiol (2022) 154 (9): e202213089.

DOI: https://doi.org/10.1085/jgp.202213089

Published: 17 June 2022

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Journal Articles

Closed-state inactivation of cardiac, skeletal, and neuronal sodium channels is isoform specific

Niklas Brake, Adamo S. Mancino, Yuhao Yan, Takushi Shimomura, Yoshihiro Kubo, Anmar Khadra, Derek Bowie

J Gen Physiol (2022) 154 (7): e202112921.

DOI: https://doi.org/10.1085/jgp.202112921

Published: 25 May 2022

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Includes: Supplementary data

Journal Articles

Probing function in ligand-gated ion channels without measuring ion transport

In Special Collection:

Biophysics 2023

Nicole E. Godellas, Claudio Grosman

J Gen Physiol (2022) 154 (6): e202213082.

DOI: https://doi.org/10.1085/jgp.202213082

Published: 25 May 2022

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A cooperative knock-on mechanism underpins Ca²⁺-selective cation permeation in TRPV channels

Probenecid affects muscle Ca²⁺ homeostasis and contraction independently from pannexin channel block

Segregation of Ca²⁺ signaling in olfactory signal transduction

Optimization of CFTR gating through the evolution of its extracellular loops

Myosin-binding protein C stabilizes, but is not the sole determinant of SRX myosin in cardiac muscle

Sarcomere length affects Ca²⁺ sensitivity of contraction in ischemic but not non-ischemic myocardium

Role of ryanodine receptor 2 and FK506-binding protein 12.6 dissociation in pulmonary hypertension

Myosin loop-4 is critical for optimal tropomyosin repositioning on actin during muscle activation and relaxation

Ion channel regulation of gut immunity

Single-molecule imaging reveals how mavacamten and PKA modulate ATP turnover in skeletal muscle myofibrils

Cardiac myosin filaments are directly regulated by calcium

The funny current I_f is essential for the fight-or-flight response in cardiac pacemaker cells

Ca_V1.2 channelopathic mutations evoke diverse pathophysiological mechanisms

Molecular-level evidence of force maintenance by smooth muscle myosin during LC₂₀ dephosphorylation

Postdevelopmental knockout of Orai1 improves muscle pathology in a mouse model of Duchenne muscular dystrophy

Expression of ENaC subunits in epithelia

A novel method for determining murine skeletal muscle fiber type using autofluorescence lifetimes

How does flecainide impact RyR2 channel function?

Closed-state inactivation of cardiac, skeletal, and neuronal sodium channels is isoform specific

Probing function in ligand-gated ion channels without measuring ion transport

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