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Journal Articles

Analogs of FTY720 inhibit TRPM7 but not S1PRs and exert multimodal anti-inflammatory effects

Gregory W. Busey, Mohan C. Manjegowda, Tao Huang, Wesley H. Iobst, Shardul S. Naphade, Joel A. Kennedy, Catherine A. Doyle, Philip V. Seegren, Kevin R. Lynch, Bimal N. Desai

J Gen Physiol (2023) 156 (1): e202313419.

https://doi.org/10.1085/jgp.202313419

Published: 09 November 2023

View article titled, Analogs of FTY720 inhibit TRPM7 but not S1PRs and exert multimodal anti-inflammatory effects

Journal Articles

Structural basis for severe pain caused by mutations in the voltage sensors of sodium channel Na_V1.7

Goragot Wisedchaisri, Tamer M. Gamal El-Din, Natasha M. Powell, Ning Zheng, William A. Catterall

J Gen Physiol (2023) 155 (12): e202313450.

https://doi.org/10.1085/jgp.202313450

Published: 30 October 2023

View article titled, Structural basis for severe pain caused by mutations in the voltage sensors of sodium channel NaV1.7

Includes: Supplementary data

Journal Articles

IP3R1 underlies diastolic ANO1 activation and pressure-dependent chronotropy in lymphatic collecting vessels

Scott D. Zawieja, Grace A. Pea, Sarah E. Broyhill, Advaya Patro, Karen H. Bromert, Min Li, Charles E. Norton, Jorge A. Castorena-Gonzalez, Edward J. Hancock, Christopher D. Bertram, Michael J. Davis

J Gen Physiol (2023) 155 (12): e202313358.

https://doi.org/10.1085/jgp.202313358

Published: 18 October 2023

View article titled, IP3R1 underlies diastolic ANO1 activation and pressure-dependent chronotropy in lymphatic collecting vessels

Includes: Supplementary data

Journal Articles

The biophysical properties of TRIC-A and TRIC-B and their interactions with RyR2

Jianshu Hu, Elisa Venturi, Charalampos Sigalas, Takashi Murayama, Miyuki Nishi, Hiroshi Takeshima, Rebecca Sitsapesan

J Gen Physiol (2023) 155 (11): e202113070.

https://doi.org/10.1085/jgp.202113070

Published: 26 September 2023

View article titled, The biophysical properties of TRIC-A and TRIC-B and their interactions with RyR2

Includes: Supplementary data

Journal Articles

Epilepsy-associated SCN2A (Na_V1.2) variants exhibit diverse and complex functional properties

In Special Collection:

Neuroscience Collection 2023

Christopher H. Thompson, Franck Potet, Tatiana V. Abramova, Jean-Marc DeKeyser, Nora F. Ghabra, Carlos G. Vanoye, John J. Millichap, Alfred L. George, Jr

J Gen Physiol (2023) 155 (10): e202313375.

https://doi.org/10.1085/jgp.202313375

Published: 14 August 2023

View article titled, Epilepsy-associated SCN2A (NaV1.2) variants exhibit diverse and complex functional properties

Includes: Supplementary data

Journal Articles

Cold and warmth intensify pain-linked sodium channel gating effects and persistent currents

In Special Collection:

Neuroscience Collection 2023 , Physiology of Pain Detection and Processing Collection 2023

Sophia Kriegeskorte, Raya Bott, Martin Hampl, Alon Korngreen, Ralf Hausmann, Angelika Lampert

J Gen Physiol (2023) 155 (9): e202213312.

https://doi.org/10.1085/jgp.202213312

Published: 02 August 2023

View article titled, Cold and warmth intensify pain-linked sodium channel gating effects and persistent currents

Includes: Supplementary data

Journal Articles

Mechanistic understanding of KCNQ1 activating polyunsaturated fatty acid analogs

Jessica J. Jowais, Samira Yazdi, Alessia Golluscio, Vanessa Olivier-Meo, Sara I. Liin, H. Peter Larsson

J Gen Physiol (2023) 155 (10): e202313339.

https://doi.org/10.1085/jgp.202313339

Published: 01 August 2023

View article titled, Mechanistic understanding of KCNQ1 activating polyunsaturated fatty acid analogs

Journal Articles

Alkali metal cations modulate the geometry of different binding sites in HCN4 selectivity filter for permeation or block

Jan H. Krumbach, Daniel Bauer, Atiyeh Sadat Sharifzadeh, Andrea Saponaro, Rene Lautenschläger, Kristina Lange, Oliver Rauh, Dario DiFrancesco, Anna Moroni, Gerhard Thiel, Kay Hamacher

J Gen Physiol (2023) 155 (10): e202313364.

https://doi.org/10.1085/jgp.202313364

Published: 31 July 2023

View article titled, Alkali metal cations modulate the geometry of different binding sites in HCN4 selectivity filter for permeation or block

Includes: Supplementary data

Journal Articles

Determinants of iFGF13-mediated regulation of myocardial voltage-gated sodium (Na_V) channels in mouse

Adrien Lesage, Maxime Lorenzini, Sophie Burel, Marine Sarlandie, Floriane Bibault, Cecilia Lindskog, Daniel Maloney, Jonathan R. Silva, R. Reid Townsend, Jeanne M. Nerbonne, Céline Marionneau

J Gen Physiol (2023) 155 (9): e202213293.

https://doi.org/10.1085/jgp.202213293

Published: 27 July 2023

View article titled, Determinants of iFGF13-mediated regulation of myocardial voltage-gated sodium (NaV) channels in mouse

Includes: Supplementary data

Journal Articles

Patch-clamp technique to study mitochondrial membrane biophysics

In Special Collection:

Physiology of Pain Detection and Processing Collection 2023

Anshu Kumari, Dung M. Nguyen, Vivek Garg

J Gen Physiol (2023) 155 (8): e202313347.

https://doi.org/10.1085/jgp.202313347

Published: 22 June 2023

View article titled, Patch-clamp technique to study mitochondrial membrane biophysics

Journal Articles

The role of Zn²⁺ in shaping intracellular Ca²⁺ dynamics in the heart

Amy M. Dorward, Alan J. Stewart, Samantha J. Pitt

J Gen Physiol (2023) 155 (7): e202213206.

https://doi.org/10.1085/jgp.202213206

Published: 16 June 2023

View article titled, The role of Zn2+ in shaping intracellular Ca2+ dynamics in the heart

Journal Articles

Interactions between selectivity filter and pore helix control filter gating in the MthK channel

Wojciech Kopec, Andrew S. Thomson, Bert L. de Groot, Brad S. Rothberg

J Gen Physiol (2023) 155 (8): e202213166.

https://doi.org/10.1085/jgp.202213166

Published: 15 June 2023

View article titled, Interactions between selectivity filter and pore helix control filter gating in the MthK channel

Journal Articles

Troponin-I–induced tropomyosin pivoting defines thin-filament function in relaxed and active muscle

William Lehman, Michael J. Rynkiewicz

J Gen Physiol (2023) 155 (7): e202313387.

https://doi.org/10.1085/jgp.202313387

Published: 30 May 2023

View article titled, Troponin-I–induced tropomyosin pivoting defines thin-filament function in relaxed and active muscle

Journal Articles

Molecular rearrangements in S6 during slow inactivation in Shaker-IR potassium channels

Tibor G. Szanto, Ferenc Papp, Florina Zakany, Zoltan Varga, Carol Deutsch, Gyorgy Panyi

J Gen Physiol (2023) 155 (7): e202313352.

https://doi.org/10.1085/jgp.202313352

Published: 22 May 2023

View article titled, Molecular rearrangements in S6 during slow inactivation in Shaker-IR potassium channels

Journal Articles

Extracellular histone proteins activate P2XR7 channel current

Rua’a Al-Aqtash, Maxwell S. Ross, Daniel M. Collier

J Gen Physiol (2023) 155 (7): e202213317.

https://doi.org/10.1085/jgp.202213317

Published: 18 May 2023

View article titled, Extracellular histone proteins activate P2XR7 channel current

Journal Articles

BK channel modulation by positively charged peptides and auxiliary γ subunits mediated by the Ca²⁺-bowl site

Guanxing Chen, Qin Li, Timothy I. Webb, Mark A. Hollywood, Jiusheng Yan

J Gen Physiol (2023) 155 (6): e202213237.

https://doi.org/10.1085/jgp.202213237

Published: 02 May 2023

View article titled, BK channel modulation by positively charged peptides and auxiliary γ subunits mediated by the Ca2+-bowl site

Includes: Supplementary data

Journal Articles

Depressed myocardial cross-bridge cycling kinetics in a female guinea pig model of diastolic heart failure

Sukriti Dewan, Namthip Witayavanitkul, Mohit Kumar, Beth J. Mayer, Lauren Betancourt, Olivier Cazorla, Pieter P. de Tombe

J Gen Physiol (2023) 155 (6): e202213288.

https://doi.org/10.1085/jgp.202213288

Published: 27 April 2023

View article titled, Depressed myocardial cross-bridge cycling kinetics in a female guinea pig model of diastolic heart failure

Includes: Supplementary data

Journal Articles

The contribution of N-terminal truncated cMyBPC to in vivo cardiac function

Katherine L. Dominic, Joohee Choi, Joshua B. Holmes, Mandeep Singh, Michael J. Majcher, Julian E. Stelzer

J Gen Physiol (2023) 155 (6): e202213318.

https://doi.org/10.1085/jgp.202213318

Published: 17 April 2023

View article titled, The contribution of N-terminal truncated cMyBPC to in vivo cardiac function

Journal Articles

PI(4,5)P₂ regulates the gating of Na_V1.4 channels

Kirin D. Gada, Jordie M. Kamuene, Aishwarya Chandrashekar, R. Charles Kissell, Anne K. Yauch, Leigh D. Plant

J Gen Physiol (2023) 155 (6): e202213255.

https://doi.org/10.1085/jgp.202213255

Published: 12 April 2023

View article titled, PI(4,5)P2 regulates the gating of NaV1.4 channels

Journal Articles

Binding motif for RIC-3 chaperon protein in serotonin type 3A receptors

Hoa Quynh Do, Michaela Jansen

J Gen Physiol (2023) 155 (6): e202213305.

https://doi.org/10.1085/jgp.202213305

Published: 07 April 2023

View article titled, Binding motif for RIC-3 chaperon protein in serotonin type 3A receptors

Includes: Supplementary data

NARROW

Filters

Analogs of FTY720 inhibit TRPM7 but not S1PRs and exert multimodal anti-inflammatory effects

Structural basis for severe pain caused by mutations in the voltage sensors of sodium channel Na_V1.7

IP3R1 underlies diastolic ANO1 activation and pressure-dependent chronotropy in lymphatic collecting vessels

The biophysical properties of TRIC-A and TRIC-B and their interactions with RyR2

Epilepsy-associated SCN2A (Na_V1.2) variants exhibit diverse and complex functional properties

Cold and warmth intensify pain-linked sodium channel gating effects and persistent currents

Mechanistic understanding of KCNQ1 activating polyunsaturated fatty acid analogs

Alkali metal cations modulate the geometry of different binding sites in HCN4 selectivity filter for permeation or block

Determinants of iFGF13-mediated regulation of myocardial voltage-gated sodium (Na_V) channels in mouse

Patch-clamp technique to study mitochondrial membrane biophysics

The role of Zn²⁺ in shaping intracellular Ca²⁺ dynamics in the heart

Interactions between selectivity filter and pore helix control filter gating in the MthK channel

Troponin-I–induced tropomyosin pivoting defines thin-filament function in relaxed and active muscle

Molecular rearrangements in S6 during slow inactivation in Shaker-IR potassium channels

Extracellular histone proteins activate P2XR7 channel current

BK channel modulation by positively charged peptides and auxiliary γ subunits mediated by the Ca²⁺-bowl site

Depressed myocardial cross-bridge cycling kinetics in a female guinea pig model of diastolic heart failure

The contribution of N-terminal truncated cMyBPC to in vivo cardiac function

PI(4,5)P₂ regulates the gating of Na_V1.4 channels

Binding motif for RIC-3 chaperon protein in serotonin type 3A receptors

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