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Journal Articles

Anionic omega currents from single countercharge mutants in the voltage-sensing domain of Ci-VSP

Rong Shen, Benoît Roux, Eduardo Perozo

J Gen Physiol (2023) 156 (1): e202213311.

https://doi.org/10.1085/jgp.202213311

Published: 29 November 2023

View article titled, Anionic omega currents from single countercharge mutants in the voltage-sensing domain of Ci-VSP

Journal Articles

Structural basis for severe pain caused by mutations in the voltage sensors of sodium channel Na_V1.7

Goragot Wisedchaisri, Tamer M. Gamal El-Din, Natasha M. Powell, Ning Zheng, William A. Catterall

J Gen Physiol (2023) 155 (12): e202313450.

https://doi.org/10.1085/jgp.202313450

Published: 30 October 2023

View article titled, Structural basis for severe pain caused by mutations in the voltage sensors of sodium channel NaV1.7

Includes: Supplementary data

Journal Articles

The structural and functional integrities of porcine myocardium are mostly preserved by cryopreservation

Weikang Ma, Kyoung Hwan Lee, Christine E. Delligatti, M. Therese Davis, Yahan Zheng, Henry Gong, Jonathan A. Kirk, Roger Craig, Thomas Irving

J Gen Physiol (2023) 155 (9): e202313345.

https://doi.org/10.1085/jgp.202313345

Published: 03 July 2023

View article titled, The structural and functional integrities of porcine myocardium are mostly preserved by cryopreservation

Journal Articles

Physical activity impacts resting skeletal muscle myosin conformation and lowers its ATP consumption

J Gen Physiol (2023) 155 (7): e202213268.

https://doi.org/10.1085/jgp.202213268

Published: 25 May 2023

View article titled, Physical activity impacts resting skeletal muscle myosin conformation and lowers its ATP consumption

Includes: Supplementary data

Journal Articles

A cooperative knock-on mechanism underpins Ca²⁺-selective cation permeation in TRPV channels

In Special Collection:

Physiology of Pain Detection and Processing Collection 2023

Callum M. Ives, Neil J. Thomson, Ulrich Zachariae

J Gen Physiol (2023) 155 (5): e202213226.

https://doi.org/10.1085/jgp.202213226

Published: 21 March 2023

View article titled, A cooperative knock-on mechanism underpins Ca2+-selective cation permeation in TRPV channels

Includes: Supplementary data

Journal Articles

Mechanism of external K⁺ sensitivity of KCNQ1 channels

Astghik Abrahamyan, Jodene Eldstrom, Harutyun Sahakyan, Nare Karagulyan, Liana Mkrtchyan, Tatev Karapetyan, Ernest Sargsyan, Matthias Kneussel, Karen Nazaryan, Jürgen R. Schwarz, David Fedida, Vitya Vardanyan

J Gen Physiol (2023) 155 (5): e202213205.

https://doi.org/10.1085/jgp.202213205

Published: 21 February 2023

View article titled, Mechanism of external K+ sensitivity of KCNQ1 channels

Includes: Supplementary data

Journal Articles

Fluorescence lifetime-based assay reports structural changes in cardiac muscle mediated by effectors of contractile regulation

Alexey V. Dvornikov, Thomas A. Bunch, Victoria C. Lepak, Brett A. Colson

J Gen Physiol (2023) 155 (3): e202113054.

https://doi.org/10.1085/jgp.202113054

Published: 12 January 2023

View article titled, Fluorescence lifetime-based assay reports structural changes in cardiac muscle mediated by effectors of contractile regulation

Includes: Supplementary data

Journal Articles

Conformational changes linked to ADP release from human cardiac myosin bound to actin-tropomyosin

Matthew H. Doran, Michael J. Rynkiewicz, David Rasicci, Skylar M.L. Bodt, Meaghan E. Barry, Esther Bullitt, Christopher M. Yengo, Jeffrey R. Moore, William Lehman

J Gen Physiol (2023) 155 (3): e202213267.

https://doi.org/10.1085/jgp.202213267

Published: 12 January 2023

View article titled, Conformational changes linked to ADP release from human cardiac myosin bound to actin-tropomyosin

Journal Articles

Multiscale molecular dynamics simulations predict arachidonic acid binding sites in human ASIC1a and ASIC3 transmembrane domains

Anna Ananchenko, Maria Musgaard

J Gen Physiol (2023) 155 (3): e202213259.

https://doi.org/10.1085/jgp.202213259

Published: 10 January 2023

View article titled, Multiscale molecular dynamics simulations predict arachidonic acid binding sites in human ASIC1a and ASIC3 transmembrane domains

Journal Articles

Mechanistic insights on K_ATP channel regulation from cryo-EM structures

Camden M. Driggers, Show-Ling Shyng

J Gen Physiol (2022) 155 (1): e202113046.

https://doi.org/10.1085/jgp.202113046

Published: 28 November 2022

View article titled, Mechanistic insights on KATP channel regulation from cryo-EM structures

Journal Articles

When is a hydrophobic gate not a hydrophobic gate?

David Seiferth, Philip C. Biggin, Stephen J. Tucker

J Gen Physiol (2022) 154 (11): e202213210.

https://doi.org/10.1085/jgp.202213210

Published: 26 October 2022

View article titled, When is a hydrophobic gate not a hydrophobic gate?

Journal Articles

How does flecainide impact RyR2 channel function?

Samantha C. Salvage, Christopher L.-H. Huang, James A. Fraser, Angela F. Dulhunty

J Gen Physiol (2022) 154 (9): e202213089.

https://doi.org/10.1085/jgp.202213089

Published: 17 June 2022

View article titled, How does flecainide impact RyR2 channel function?

Journal Articles

Physics of mechanotransduction by Piezo ion channels

Michael Young, Amanda H. Lewis, Jörg Grandl

J Gen Physiol (2022) 154 (7): e202113044.

https://doi.org/10.1085/jgp.202113044

Published: 20 May 2022

View article titled, Physics of mechanotransduction by Piezo ion channels

Journal Articles

EVAP: A two-photon imaging tool to study conformational changes in endogenous Kv2 channels in live tissues

In Special Collection:

Neuroscience Collection 2022

Parashar Thapa, Robert Stewart, Rebecka J. Sepela, Oscar Vivas, Laxmi K. Parajuli, Mark Lillya, Sebastian Fletcher-Taylor, Bruce E. Cohen, Karen Zito, Jon T. Sack

J Gen Physiol (2021) 153 (11): e202012858.

https://doi.org/10.1085/jgp.202012858

Published: 28 September 2021

View article titled, EVAP: A two-photon imaging tool to study conformational changes in endogenous Kv2 channels in live tissues

Includes: Supplementary data

Journal Articles

Protein functional dynamics from the rigorous global analysis of DEER data: Conditions, components, and conformations

Eric J. Hustedt, Richard A. Stein, Hassane S. Mchaourab

J Gen Physiol (2021) 153 (11): e201711954.

https://doi.org/10.1085/jgp.201711954

Published: 16 September 2021

View article titled, Protein functional dynamics from the rigorous global analysis of DEER data: Conditions, components, and conformations

Journal Articles

Conformations of voltage-sensing domain III differentially define Na_V channel closed- and open-state inactivation

Paweorn Angsutararux, Po Wei Kang, Wandi Zhu, Jonathan R. Silva

J Gen Physiol (2021) 153 (9): e202112891.

https://doi.org/10.1085/jgp.202112891

Published: 04 August 2021

View article titled, Conformations of voltage-sensing domain III differentially define NaV channel closed- and open-state inactivation

Journal Articles

Zinc binding alters the conformational dynamics and drives the transport cycle of the cation diffusion facilitator YiiP

Maria Lopez-Redondo, Shujie Fan, Akiko Koide, Shohei Koide, Oliver Beckstein, David L. Stokes

J Gen Physiol (2021) 153 (8): e202112873.

https://doi.org/10.1085/jgp.202112873

Published: 13 July 2021

View article titled, Zinc binding alters the conformational dynamics and drives the transport cycle of the cation diffusion facilitator YiiP

Journal Articles

Shaker-IR K⁺ channel gating in heavy water: Role of structural water molecules in inactivation

Tibor G. Szanto, Szabolcs Gaal, Izhar Karbat, Zoltan Varga, Eitan Reuveny, Gyorgy Panyi

J Gen Physiol (2021) 153 (6): e202012742.

https://doi.org/10.1085/jgp.202012742

Published: 20 May 2021

View article titled, Shaker-IR K+ channel gating in heavy water: Role of structural water molecules in inactivation

Includes: Supplementary data

Journal Articles

Structure versus function: Are new conformations of pannexin 1 yet to be resolved?

Carsten Mim, Guy Perkins, Gerhard Dahl

J Gen Physiol (2021) 153 (5): e202012754.

https://doi.org/10.1085/jgp.202012754

Published: 09 April 2021

View article titled, Structure versus function: Are new conformations of pannexin 1 yet to be resolved?

Journal Articles

The N2A region of titin has a unique structural configuration

In Special Collection:

Biophysics 2022

Chiara Stronczek, Stephan Lange, Belinda Bullard, Sebastian Wolniak, Emma Börgeson, Olga Mayans, Jennifer R. Fleming

J Gen Physiol (2021) 153 (7): e202012766.

https://doi.org/10.1085/jgp.202012766

Published: 09 April 2021

View article titled, The N2A region of titin has a unique structural configuration

NARROW

Anionic omega currents from single countercharge mutants in the voltage-sensing domain of Ci-VSP

Structural basis for severe pain caused by mutations in the voltage sensors of sodium channel Na_V1.7

The structural and functional integrities of porcine myocardium are mostly preserved by cryopreservation

Physical activity impacts resting skeletal muscle myosin conformation and lowers its ATP consumption

A cooperative knock-on mechanism underpins Ca²⁺-selective cation permeation in TRPV channels

Mechanism of external K⁺ sensitivity of KCNQ1 channels

Fluorescence lifetime-based assay reports structural changes in cardiac muscle mediated by effectors of contractile regulation

Conformational changes linked to ADP release from human cardiac myosin bound to actin-tropomyosin

Multiscale molecular dynamics simulations predict arachidonic acid binding sites in human ASIC1a and ASIC3 transmembrane domains

Mechanistic insights on K_ATP channel regulation from cryo-EM structures

When is a hydrophobic gate not a hydrophobic gate?

How does flecainide impact RyR2 channel function?

Physics of mechanotransduction by Piezo ion channels

EVAP: A two-photon imaging tool to study conformational changes in endogenous Kv2 channels in live tissues

Protein functional dynamics from the rigorous global analysis of DEER data: Conditions, components, and conformations

Conformations of voltage-sensing domain III differentially define Na_V channel closed- and open-state inactivation

Zinc binding alters the conformational dynamics and drives the transport cycle of the cation diffusion facilitator YiiP

Shaker-IR K⁺ channel gating in heavy water: Role of structural water molecules in inactivation

Structure versus function: Are new conformations of pannexin 1 yet to be resolved?

The N2A region of titin has a unique structural configuration

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