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Table 1

>T and B Lymphocyte Differentiation Is Normal in IL-10 Transgenic Mice

Mouse typeCell no.CD4+CD8+CD4+/CD8+B220/IgM+
Thymus    %  %  %  % 
 Control No. 1     1 × 108   9.8   2.6  83.7  – 
 Control No. 2  1.2 × 108  10.9   2.6  82.7  – 
 IL-10 Tg No. 1  9.8 × 107  10.4   3.2  82.1  – 
 IL-10 Tg No. 2  1.6 × 108  15.3   3.4  77.4  – 
Spleen           
 Control No. 1  4.8 × 107  26.6  17.5  <1  60.8 
 Control No. 3  5.5 × 107  22.8   9.7  <1  61.8 
 Control No. 4  5.4 × 107  19.5  14.4  <1  60.3 
 IL-10 Tg No. 1  3.0 × 107  22.8  13.2  <1  62.8 
 IL-10 Tg No. 2  3.0 × 107  24.9  13.2  <1  58.4 
 IL-10 Tg No. 3  6.5 × 107  16.5  10.3  <1  63.7 
 IL-10 Tg No. 4  6.5 × 107  23.4  14.6  <1  50.5 
Mouse typeCell no.CD4+CD8+CD4+/CD8+B220/IgM+
Thymus    %  %  %  % 
 Control No. 1     1 × 108   9.8   2.6  83.7  – 
 Control No. 2  1.2 × 108  10.9   2.6  82.7  – 
 IL-10 Tg No. 1  9.8 × 107  10.4   3.2  82.1  – 
 IL-10 Tg No. 2  1.6 × 108  15.3   3.4  77.4  – 
Spleen           
 Control No. 1  4.8 × 107  26.6  17.5  <1  60.8 
 Control No. 3  5.5 × 107  22.8   9.7  <1  61.8 
 Control No. 4  5.4 × 107  19.5  14.4  <1  60.3 
 IL-10 Tg No. 1  3.0 × 107  22.8  13.2  <1  62.8 
 IL-10 Tg No. 2  3.0 × 107  24.9  13.2  <1  58.4 
 IL-10 Tg No. 3  6.5 × 107  16.5  10.3  <1  63.7 
 IL-10 Tg No. 4  6.5 × 107  23.4  14.6  <1  50.5 

Cells from spleen and thymus of line 9 IL-10 transgenic (Tg) mice were prepared, counted, and stained with the various cell-surface markers. Stained cells were analyzed by flow cytometry as described in Materials and Methods. Values are given as percentages of total gated lymphocyte populations, based on light scatter. –, not done.  

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