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Table 1

Histological Features of GN in Mice

Group	Glomerular crescent formation	PAS+ Material (0-3+)	Glomerular Hypercellularity	Glomerular Macrophages
	% glomeruli		cells/gcs	cells/gcs
WT (Plg)	4.8 ± 1.9	0.79 ± 0.08	66.3 ± 1.2	1.47 ± 0.17
Plg −/−	18.1 ± 3.1^*	1.94 ± 0.27^*	54.0 ± 1.9^‡	4.85 ± 1.03^*

WT (tPA, uPA)	2.9 ± 1.2	0.64 ± 0.09	58.6 ± 2.8	1.38 ± 0.05
tPA−/−:uPA−/−	15.4 ± 2.9^§	1.55 ± 0.24^§	45.3 ± 4.4^*	3.92 ± 0.52^¶

WT	3.9 ± 1.9	0.75 ± 0.20	60.1 ± 1.2	1.46 ± 0.14
tPA−/−	16.1 ± 8.0	1.27 ± 0.05^¶	69.7 ± 1.6^¶	2.22 ± 0.28^‡
uPA−/−	6.1 ± 1.3	0.80 ± 0.07	62.4 ± 2.2	0.82 ± 0.08^*
uPAR−/−	9.6 ± 3.5	0.87 ± 0.06	64.8 ± 2.3	1.31 ± 0.18

Group	Glomerular crescent formation	PAS+ Material (0-3+)	Glomerular Hypercellularity	Glomerular Macrophages
	% glomeruli		cells/gcs	cells/gcs
WT (Plg)	4.8 ± 1.9	0.79 ± 0.08	66.3 ± 1.2	1.47 ± 0.17
Plg −/−	18.1 ± 3.1^*	1.94 ± 0.27^*	54.0 ± 1.9^‡	4.85 ± 1.03^*

WT (tPA, uPA)	2.9 ± 1.2	0.64 ± 0.09	58.6 ± 2.8	1.38 ± 0.05
tPA−/−:uPA−/−	15.4 ± 2.9^§	1.55 ± 0.24^§	45.3 ± 4.4^*	3.92 ± 0.52^¶

WT	3.9 ± 1.9	0.75 ± 0.20	60.1 ± 1.2	1.46 ± 0.14
tPA−/−	16.1 ± 8.0	1.27 ± 0.05^¶	69.7 ± 1.6^¶	2.22 ± 0.28^‡
uPA−/−	6.1 ± 1.3	0.80 ± 0.07	62.4 ± 2.2	0.82 ± 0.08^*
uPAR−/−	9.6 ± 3.5	0.87 ± 0.06	64.8 ± 2.3	1.31 ± 0.18

Comparison of histological features of GN in plasminogen (Plg−/−), combined plasminogen activator-deficient (tPA−/−:uPA−/−), tPA (tPA−/−), uPA (uPA−/−) and uPA receptor (uPAR−/−)-deficient mice and their appropriate WT controls. Results are expressed as the mean ± SEM.

Results significantly different to WT at the P <0.05 level;

‡

P <0.01 level;

P <0.005 level;

P <0.001 level (Fisher's PLSD test).

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