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Table 1

Histological Features of GN in Mice

GroupGlomerular crescent formationPAS+ Material (0-3+)Glomerular HypercellularityGlomerular Macrophages
  % glomeruli    cells/gcs  cells/gcs 
WT (Plg)    4.8 ± 1.9    0.79 ± 0.08         66.3 ± 1.2  1.47 ± 0.17 
Plg −/−      18.1 ± 3.1*  1.94 ± 0.27*    54.0 ± 1.9  4.85 ± 1.03* 
         
WT (tPA, uPA)   2.9 ± 1.2    0.64 ± 0.09  58.6 ± 2.8  1.38 ± 0.05 
tPA−/−:uPA−/−      15.4 ± 2.9§    1.55 ± 0.24§     45.3 ± 4.4*  3.92 ± 0.52 
         
WT   3.9 ± 1.9    0.75 ± 0.20         60.1 ± 1.2  1.46 ± 0.14 
tPA−/−  16.1 ± 8.0    1.27 ± 0.05  69.7 ± 1.6  2.22 ± 0.28 
uPA−/−   6.1 ± 1.3    0.80 ± 0.07    62.4 ± 2.2  0.82 ± 0.08* 
uPAR−/−   9.6 ± 3.5    0.87 ± 0.06    64.8 ± 2.3  1.31 ± 0.18 
GroupGlomerular crescent formationPAS+ Material (0-3+)Glomerular HypercellularityGlomerular Macrophages
  % glomeruli    cells/gcs  cells/gcs 
WT (Plg)    4.8 ± 1.9    0.79 ± 0.08         66.3 ± 1.2  1.47 ± 0.17 
Plg −/−      18.1 ± 3.1*  1.94 ± 0.27*    54.0 ± 1.9  4.85 ± 1.03* 
         
WT (tPA, uPA)   2.9 ± 1.2    0.64 ± 0.09  58.6 ± 2.8  1.38 ± 0.05 
tPA−/−:uPA−/−      15.4 ± 2.9§    1.55 ± 0.24§     45.3 ± 4.4*  3.92 ± 0.52 
         
WT   3.9 ± 1.9    0.75 ± 0.20         60.1 ± 1.2  1.46 ± 0.14 
tPA−/−  16.1 ± 8.0    1.27 ± 0.05  69.7 ± 1.6  2.22 ± 0.28 
uPA−/−   6.1 ± 1.3    0.80 ± 0.07    62.4 ± 2.2  0.82 ± 0.08* 
uPAR−/−   9.6 ± 3.5    0.87 ± 0.06    64.8 ± 2.3  1.31 ± 0.18 

Comparison of histological features of GN in plasminogen (Plg−/−), combined plasminogen activator-deficient (tPA−/−:uPA−/−), tPA (tPA−/−), uPA (uPA−/−) and uPA receptor (uPAR−/−)-deficient mice and their appropriate WT controls. Results are expressed as the mean ± SEM.  

*

 Results significantly different to WT at the P <0.05 level;  

  P <0.01 level;  

§

P <0.005 level;  

P <0.001 level (Fisher's PLSD test).  

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