Rockefeller University Press

Table 1

Passive Protection of Balb/c Mice Conferred by mAb Me-1 Against Infection with N. meningitidis Strain 608B

Groups	Number of living mice after the bacterial challenge^*		% of survival (range)^‡
Groups	24 h	72 h	% of survival (range)^‡
Me-1–injected mice^§	29/30	23/30	76
			(60–100)
Control mice^‖	10/30	9/30	30
			(0–40)

Groups	Number of living mice after the bacterial challenge^*		% of survival (range)^‡
Groups	24 h	72 h	% of survival (range)^‡
Me-1–injected mice^§	29/30	23/30	76
			(60–100)
Control mice^‖	10/30	9/30	30
			(0–40)

The mice were challenged with 1 ml of a suspension containing 1,000 CFU of N. meningitidis strain 608B, 4% mucin (Sigma), and 1.6% hemoglobin (Oxoid).

‡

Combined results of three separate protection experiments. The range indicates the lowest and highest survival rates obtained.

600 μl of ascitic fluid containing mAb Me-1 were injected intraperitoneally 18 h before the bacterial challenge.

‖

The mice in the control group received 600 μl of ascitic fluid containing unrelated mAb or phosphate buffered saline.

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