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Table 2

Deduced Amino Acid Sequence around SLYNTVATL Epitope from Proviral DNA Sequence in Responders and Nonresponders

DonorHLA class I A and B typeTimepointDeduced amino acid sequence% Provial DNA clones
SLYNTVATL Responders         
003  A2/3 B7/51  07/87  GSEELRSLYNTVATLYCVHQR  100%  n = 8 
    06/95  GSEELRSLYNTVATLYCVHQR   82%  n = 13 
      GSEERKSLYNTVATLYCVHQR    6%  n = 1 
      GSEELRSLLNTVATLYCVHQR    6%  n = 1 
      GSEELKSLYNTVATLYCVHKR    6%  n = 1 
    12/95  GSEELRSLYNTVATLYCVHQR  100%  n = 16 
    06/96  GSEELRSLYNTVATLYCVHQR  100%  n = 5 
077  A2/3 B41/49  12/94  GSEELRSLYNTVATLYCVHQR  100%  n = 3 
1M  A2/1 B7/57  08/96  GSEERKSLYNTVATLYCVHQK  100%  n = 4 
5M  A2/32 B7/57  10/93  GSEELRSLYNTIAVLYCVHQR   90%  n = 28 
      GSEELRSLYNTVAVLYCVHQR   10%  n = 3 
    11/95  GSEEVRSLYNTVATLYCVHQR  100%  n = 4 
868  A2/24 B27/35  10/95  GSEELRSLYNTVATLYCVHQR   73%  n = 8 
      GSEELRSLYNTIATLYCVHQR    9%  n = 1 
      GSEELKSLYNTIATLYCVHQR    9%  n = 1 
      GSEERKSLYNTVATLYCVHQR    9%  n = 1 
    04/96  GSEELRSLYNTIAVLYCVHQR   92%  n = 11 
      GSEELKSLYNTIATLYCVHQR    8%  n = 1 
    08/96  GSEELKSLYNTVATLYCVHQR  100%  n = 5 
SLYNTVATL Nonresponders       
023  A2/3 B7/51  07/87  GSEKLKSLHNTVATLYCVHQR  100%  n = 3 
    06/95  GSEELQSLHNAVAVLYCVHQR   70%  n = 7 
      GSEELESLYNTVATLYCVHQR   10%  n = 1 
      GSEELKSLYNTVATLYCVHQR   10%  n = 1 
      GSEELKSLSNTIATLYCVHQR   10%  n = 1 
    12/95  GSEELQSLHNAVAVLYCVHQR  100%  n = 10 
    07/96  GSEELQSLHNAVAVLYCVHQR  100%  n = 16 
008  A2/68 B8/65  04/91  GSEEFRSLFNTVATLYCVHQR   50%  n = 3 
DonorHLA class I A and B typeTimepointDeduced amino acid sequence% Provial DNA clones
SLYNTVATL Responders         
003  A2/3 B7/51  07/87  GSEELRSLYNTVATLYCVHQR  100%  n = 8 
    06/95  GSEELRSLYNTVATLYCVHQR   82%  n = 13 
      GSEERKSLYNTVATLYCVHQR    6%  n = 1 
      GSEELRSLLNTVATLYCVHQR    6%  n = 1 
      GSEELKSLYNTVATLYCVHKR    6%  n = 1 
    12/95  GSEELRSLYNTVATLYCVHQR  100%  n = 16 
    06/96  GSEELRSLYNTVATLYCVHQR  100%  n = 5 
077  A2/3 B41/49  12/94  GSEELRSLYNTVATLYCVHQR  100%  n = 3 
1M  A2/1 B7/57  08/96  GSEERKSLYNTVATLYCVHQK  100%  n = 4 
5M  A2/32 B7/57  10/93  GSEELRSLYNTIAVLYCVHQR   90%  n = 28 
      GSEELRSLYNTVAVLYCVHQR   10%  n = 3 
    11/95  GSEEVRSLYNTVATLYCVHQR  100%  n = 4 
868  A2/24 B27/35  10/95  GSEELRSLYNTVATLYCVHQR   73%  n = 8 
      GSEELRSLYNTIATLYCVHQR    9%  n = 1 
      GSEELKSLYNTIATLYCVHQR    9%  n = 1 
      GSEERKSLYNTVATLYCVHQR    9%  n = 1 
    04/96  GSEELRSLYNTIAVLYCVHQR   92%  n = 11 
      GSEELKSLYNTIATLYCVHQR    8%  n = 1 
    08/96  GSEELKSLYNTVATLYCVHQR  100%  n = 5 
SLYNTVATL Nonresponders       
023  A2/3 B7/51  07/87  GSEKLKSLHNTVATLYCVHQR  100%  n = 3 
    06/95  GSEELQSLHNAVAVLYCVHQR   70%  n = 7 
      GSEELESLYNTVATLYCVHQR   10%  n = 1 
      GSEELKSLYNTVATLYCVHQR   10%  n = 1 
      GSEELKSLSNTIATLYCVHQR   10%  n = 1 
    12/95  GSEELQSLHNAVAVLYCVHQR  100%  n = 10 
    07/96  GSEELQSLHNAVAVLYCVHQR  100%  n = 16 
008  A2/68 B8/65  04/91  GSEEFRSLFNTVATLYCVHQR   50%  n = 3 
DonorHLA class I A and B typeTimepointDeduced amino acid sequence% Proviral DNA clones
      GSEEFRSLFNTVATLYCVHQK   17%  n = 1 
      GSEEFRSLLNTVATLYCVHQR   17%  n = 1 
      GSEEFRSLSNTVATLYCVHQR   17%  n = 1 
    04/92  GSEELKSLFNTVAVLYCVHQR   38%  n = 8 
      GSEELRSLFNTVAVLYCVHQR   19%  n = 4 
      GSEELKSLFNTIAVLYCVHQR   10%  n = 2 
      GSEEFRSLFNTVATLYCVHQR    5%  n = 1 
      GSEELKSLFNTVATLYCVHQR   14%  n = 3 
      GSEELRSLYNTIAVLYCVHQR   14%  n = 3 
065  A2/1 B8/44  02/93  GSEELKSLYNTVATLYCVHQR  100%  n = 28 
    08/94  GSEELKSLYNTVATLYCVHQR  100%  n = 1 
    05/96  GSEELKSLYNTVATLYCVHQR  100%  n = 2 
      GSEELRSLYNTVATLYCVHQR  100%  n = 1 
241  A2/26 B39/62  02/93  GSEELKSLYNTIATLYCVHQQ  100%  n = 6 
606  A2/- B62/65  10/94  GSEELKSLFNTVATLYCVHKR   75%  n = 3 
      GSEELKSLFNTVAVLYCVHKR   25%  n = 1 
SLYNTVATL Responder Switched to Nonresponder     
46M  A2/1 B8/62  09/94  GSEELRSLYNTVATLYCVHQR   33%  n = 6 
      GSEELKSLYNTVATLYCVHQR   17%  n = 3 
      GSEELRSLFNTVATLYCVHQR   11%  n = 2 
      GSEELKSLFNTVATLYCVHQR   39%  n = 7 
    06/95  GSEELKSLFNTVATLYCVHQR  100%  n = 2 
    04/96  GTEELRSLFNTVATLYCVHQR  100%  n = 3 
DonorHLA class I A and B typeTimepointDeduced amino acid sequence% Proviral DNA clones
      GSEEFRSLFNTVATLYCVHQK   17%  n = 1 
      GSEEFRSLLNTVATLYCVHQR   17%  n = 1 
      GSEEFRSLSNTVATLYCVHQR   17%  n = 1 
    04/92  GSEELKSLFNTVAVLYCVHQR   38%  n = 8 
      GSEELRSLFNTVAVLYCVHQR   19%  n = 4 
      GSEELKSLFNTIAVLYCVHQR   10%  n = 2 
      GSEEFRSLFNTVATLYCVHQR    5%  n = 1 
      GSEELKSLFNTVATLYCVHQR   14%  n = 3 
      GSEELRSLYNTIAVLYCVHQR   14%  n = 3 
065  A2/1 B8/44  02/93  GSEELKSLYNTVATLYCVHQR  100%  n = 28 
    08/94  GSEELKSLYNTVATLYCVHQR  100%  n = 1 
    05/96  GSEELKSLYNTVATLYCVHQR  100%  n = 2 
      GSEELRSLYNTVATLYCVHQR  100%  n = 1 
241  A2/26 B39/62  02/93  GSEELKSLYNTIATLYCVHQQ  100%  n = 6 
606  A2/- B62/65  10/94  GSEELKSLFNTVATLYCVHKR   75%  n = 3 
      GSEELKSLFNTVAVLYCVHKR   25%  n = 1 
SLYNTVATL Responder Switched to Nonresponder     
46M  A2/1 B8/62  09/94  GSEELRSLYNTVATLYCVHQR   33%  n = 6 
      GSEELKSLYNTVATLYCVHQR   17%  n = 3 
      GSEELRSLFNTVATLYCVHQR   11%  n = 2 
      GSEELKSLFNTVATLYCVHQR   39%  n = 7 
    06/95  GSEELKSLFNTVATLYCVHQR  100%  n = 2 
    04/96  GTEELRSLFNTVATLYCVHQR  100%  n = 3 

Continued 

Proviral DNA sequences and the encoded amino acid sequences at the region of the Gag epitope for five Gag responders, five nonresponders, and one donor whose Gag response disappeared between the first timepoint and the last; showing the timepoint (mo/yr), amino acid sequence (SLYNTVATL epitope underlined, with six amino acids either side of the epitope shown; differences from HIVLAI sequence shown in bold); number of clones sequenced, and proportion encoding a particular amino acid sequence.  

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