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Table 1

Hematopoietic Progenitor Cells

FemurSpleen
+/++/−−/−+/++/−−/−
Nucleated cells (× 10−6 18.5 ± 1.1  18.2 ± 1.6 [1.0]       16.9 ± 0.9 [0.9]  152.6 ± 15.8  141.1 ± 11.4 [0.9]  131.6 ± 10.7 [0.9] 
Progenitors × 10−3  per femur or spleen 
  CFU-GM  32.5 ± 4.3  34.5 ± 1.5 [1.1]  *45.5 ± 4.1 [1.4]  11.2 ± 3.2  11.2 ± 2.0 [1.0]  19.9 ± 6.3 [1.8] 
  BFU-E   8.2 ± 1.5  11.9 ± 0.9 [1.5]  *12.5 ± 1.6 [1.5]       9.8 ± 3.2       8.8 ± 2.6 [0.9]  10.9 ± 3.3 [1.1] 
  CFU-GEMM   2.9 ± 0.5   2.8 ± 0.3 [1.0]        *6.4 ± 0.6 [2.2]       1.2 ± 0.4       1.0 ± 0.3 [0.8]       2.1 ± 1.1 [1.8] 
Cycling status (percent of  progenitors in S-phase) 
  CFU-GM   4 ± 2      *17 ± 7 [4.3]     *64 ± 2 [16.0]       5 ± 2      *35 ± 4 [7.0]  *63 ± 4 [12.6] 
  BFU-E   6 ± 3      *35 ± 6 [5.8]     *64 ± 3 [10.7]       4 ± 2      *29 ± 5 [7.3]  *61 ± 4 [15.3] 
  CFU-GEMM   7 ± 5      *45 ± 5 [6.4]     *73 ± 2 [10.4]       7 ± 4      *42 ± 5 [6.0]      *68 ± 6 [9.7] 
FemurSpleen
+/++/−−/−+/++/−−/−
Nucleated cells (× 10−6 18.5 ± 1.1  18.2 ± 1.6 [1.0]       16.9 ± 0.9 [0.9]  152.6 ± 15.8  141.1 ± 11.4 [0.9]  131.6 ± 10.7 [0.9] 
Progenitors × 10−3  per femur or spleen 
  CFU-GM  32.5 ± 4.3  34.5 ± 1.5 [1.1]  *45.5 ± 4.1 [1.4]  11.2 ± 3.2  11.2 ± 2.0 [1.0]  19.9 ± 6.3 [1.8] 
  BFU-E   8.2 ± 1.5  11.9 ± 0.9 [1.5]  *12.5 ± 1.6 [1.5]       9.8 ± 3.2       8.8 ± 2.6 [0.9]  10.9 ± 3.3 [1.1] 
  CFU-GEMM   2.9 ± 0.5   2.8 ± 0.3 [1.0]        *6.4 ± 0.6 [2.2]       1.2 ± 0.4       1.0 ± 0.3 [0.8]       2.1 ± 1.1 [1.8] 
Cycling status (percent of  progenitors in S-phase) 
  CFU-GM   4 ± 2      *17 ± 7 [4.3]     *64 ± 2 [16.0]       5 ± 2      *35 ± 4 [7.0]  *63 ± 4 [12.6] 
  BFU-E   6 ± 3      *35 ± 6 [5.8]     *64 ± 3 [10.7]       4 ± 2      *29 ± 5 [7.3]  *61 ± 4 [15.3] 
  CFU-GEMM   7 ± 5      *45 ± 5 [6.4]     *73 ± 2 [10.4]       7 ± 4      *42 ± 5 [6.0]      *68 ± 6 [9.7] 

Nucleated cellularity and numbers and cycling status of myeloid progenitor cells in the femur and spleen of μ opioid receptor Oprm+/+, Oprm+/−, and Oprm−/− mice. Results are shown as the mean ± SEM for 14 mice (from a total of three experiments) each for Oprm+/+ and Oprm−/− and for 4 mice (from one experiment) for Oprm+/− in which each mouse was assessed individually. Numbers in brackets signify fold change from Oprm+/+ cells.  

*

 Significant difference (P <0.05, Student's t test) from wild-type value.  

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