Table 1

Chemokine Cleavage Products after Digestion with sCD26

ChemokineNH2-terminal dipeptideCD26 cleavageMolecular masses by mass spectrometry (Da)
Full lengthTruncated
TheoreticalObservedTheoreticalObserved
Eotaxin  GP  Yes  8,361  8,361  8,207  8,207 
IP-10  VP  Yes  8,633  8,637/8,751*  8,437  8,440/8,555* 
MCP-1  QP  No  8,681  8,678  8,456  ND§ 
MCP-2  QP  Yes  8,910  8,909  8,685  8,686/8,703 
ChemokineNH2-terminal dipeptideCD26 cleavageMolecular masses by mass spectrometry (Da)
Full lengthTruncated
TheoreticalObservedTheoreticalObserved
Eotaxin  GP  Yes  8,361  8,361  8,207  8,207 
IP-10  VP  Yes  8,633  8,637/8,751*  8,437  8,440/8,555* 
MCP-1  QP  No  8,681  8,678  8,456  ND§ 
MCP-2  QP  Yes  8,910  8,909  8,685  8,686/8,703 
*

Tentatively identified as [M + trifluoroacetic acid (TFA)]+; molecular mass of TFA is 114 Daltons.  

Tentatively identified as [M + H2O]+.  

§

ND, not detected.  

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