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Table 1

Mutations in VκOx1 Genes from MSH2-deficient Mice

CloneNumberPosition*
M42   1  C30T 
M70   1  G160A 
M5   2  G37T, C97A 
M53   4  G25C, C97A, A104T, G227A 
M128   5  G37A, C78T, C97A, A104T, G227A 
M89   5  G25A, C78T, C97A, A104T, G227A 
M34   5  G77A, A87T, G89C, C97A, C261T 
M71   5  G25A, G96A, C99G, A104T, G119C 
M95   6  G227A, G235A, G264A, G267A, G269A, G270T 
M106   6  T-129A, G166A, C176T, G195A, A226C, C228A 
M85   7  G71C, G73C, C78T, G96A, C99G, A104T, G227A 
M11   7  C20A, G71T, C99G, C122T, C126A, G175A, G227A 
M23   7  G25A, G96A, C99G, A104T, G166A, C176T, G227C 
M10   7  G-79T, C78G, C99G, A104T, G119C, C225T, G227A 
M36   7  G-125A, C-122T, G25A, G96A, C99G, A104T, G119C 
M115   7  C41T, C43T, C69T, C97A, G166A, C176T, G227C 
M117   7  C60A, C66T, T72G, G96A, T115C, C120A, A121T 
M120   7  G71A, G73A, G77A, G83A, G89A, C105T, C204T 
M101   8  C41T, C43T, G96A, C99A, C105T, G166A, G224A, C228T 
M119   8  G68A, G77C, C99G, A104T, G108A, A207T, G224A, G207A 
M64   9  C78T, G83C, G96A, C120T, C123T, C125T, G175A, G224A, G227A 
M82  14  G71C, G73C, C78T, C80T, G96A, C99G, A104T, C123T, C126T, A133T, G134T, A217T, G224A, G227A 
CloneNumberPosition*
M42   1  C30T 
M70   1  G160A 
M5   2  G37T, C97A 
M53   4  G25C, C97A, A104T, G227A 
M128   5  G37A, C78T, C97A, A104T, G227A 
M89   5  G25A, C78T, C97A, A104T, G227A 
M34   5  G77A, A87T, G89C, C97A, C261T 
M71   5  G25A, G96A, C99G, A104T, G119C 
M95   6  G227A, G235A, G264A, G267A, G269A, G270T 
M106   6  T-129A, G166A, C176T, G195A, A226C, C228A 
M85   7  G71C, G73C, C78T, G96A, C99G, A104T, G227A 
M11   7  C20A, G71T, C99G, C122T, C126A, G175A, G227A 
M23   7  G25A, G96A, C99G, A104T, G166A, C176T, G227C 
M10   7  G-79T, C78G, C99G, A104T, G119C, C225T, G227A 
M36   7  G-125A, C-122T, G25A, G96A, C99G, A104T, G119C 
M115   7  C41T, C43T, C69T, C97A, G166A, C176T, G227C 
M117   7  C60A, C66T, T72G, G96A, T115C, C120A, A121T 
M120   7  G71A, G73A, G77A, G83A, G89A, C105T, C204T 
M101   8  C41T, C43T, G96A, C99A, C105T, G166A, G224A, C228T 
M119   8  G68A, G77C, C99G, A104T, G108A, A207T, G224A, G207A 
M64   9  C78T, G83C, G96A, C120T, C123T, C125T, G175A, G224A, G227A 
M82  14  G71C, G73C, C78T, C80T, G96A, C99G, A104T, C123T, C126T, A133T, G134T, A217T, G224A, G227A 

Total = 22 clones (10,252 bp); 135 mutations; 1.3% mutations/bp.  

*

 Mutations are listed with the first letter representing the germline nucleotide, the number depicting the position of the mutation as shown in Fig. 2, and the second letter signifying the mutant nucleotide. Negative numbers correspond to mutations in the 5′ intron (17). Tandem mutations are underlined.  

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