Mutations in VκOx1 Genes from MSH2-deficient Mice
| Clone . | . | Number . | . | Position* . |
|---|---|---|---|---|
| M42 | 1 | C30T | ||
| M70 | 1 | G160A | ||
| M5 | 2 | G37T, C97A | ||
| M53 | 4 | G25C, C97A, A104T, G227A | ||
| M128 | 5 | G37A, C78T, C97A, A104T, G227A | ||
| M89 | 5 | G25A, C78T, C97A, A104T, G227A | ||
| M34 | 5 | G77A, A87T, G89C, C97A, C261T | ||
| M71 | 5 | G25A, G96A, C99G, A104T, G119C | ||
| M95 | 6 | G227A, G235A, G264A, G267A, G269A, G270T | ||
| M106 | 6 | T-129A, G166A, C176T, G195A, A226C, C228A | ||
| M85 | 7 | G71C, G73C, C78T, G96A, C99G, A104T, G227A | ||
| M11 | 7 | C20A, G71T, C99G, C122T, C126A, G175A, G227A | ||
| M23 | 7 | G25A, G96A, C99G, A104T, G166A, C176T, G227C | ||
| M10 | 7 | G-79T, C78G, C99G, A104T, G119C, C225T, G227A | ||
| M36 | 7 | G-125A, C-122T, G25A, G96A, C99G, A104T, G119C | ||
| M115 | 7 | C41T, C43T, C69T, C97A, G166A, C176T, G227C | ||
| M117 | 7 | C60A, C66T, T72G, G96A, T115C, C120A, A121T | ||
| M120 | 7 | G71A, G73A, G77A, G83A, G89A, C105T, C204T | ||
| M101 | 8 | C41T, C43T, G96A, C99A, C105T, G166A, G224A, C228T | ||
| M119 | 8 | G68A, G77C, C99G, A104T, G108A, A207T, G224A, G207A | ||
| M64 | 9 | C78T, G83C, G96A, C120T, C123T, C125T, G175A, G224A, G227A | ||
| M82 | 14 | G71C, G73C, C78T, C80T, G96A, C99G, A104T, C123T, C126T, A133T, G134T, A217T, G224A, G227A |
| Clone . | . | Number . | . | Position* . |
|---|---|---|---|---|
| M42 | 1 | C30T | ||
| M70 | 1 | G160A | ||
| M5 | 2 | G37T, C97A | ||
| M53 | 4 | G25C, C97A, A104T, G227A | ||
| M128 | 5 | G37A, C78T, C97A, A104T, G227A | ||
| M89 | 5 | G25A, C78T, C97A, A104T, G227A | ||
| M34 | 5 | G77A, A87T, G89C, C97A, C261T | ||
| M71 | 5 | G25A, G96A, C99G, A104T, G119C | ||
| M95 | 6 | G227A, G235A, G264A, G267A, G269A, G270T | ||
| M106 | 6 | T-129A, G166A, C176T, G195A, A226C, C228A | ||
| M85 | 7 | G71C, G73C, C78T, G96A, C99G, A104T, G227A | ||
| M11 | 7 | C20A, G71T, C99G, C122T, C126A, G175A, G227A | ||
| M23 | 7 | G25A, G96A, C99G, A104T, G166A, C176T, G227C | ||
| M10 | 7 | G-79T, C78G, C99G, A104T, G119C, C225T, G227A | ||
| M36 | 7 | G-125A, C-122T, G25A, G96A, C99G, A104T, G119C | ||
| M115 | 7 | C41T, C43T, C69T, C97A, G166A, C176T, G227C | ||
| M117 | 7 | C60A, C66T, T72G, G96A, T115C, C120A, A121T | ||
| M120 | 7 | G71A, G73A, G77A, G83A, G89A, C105T, C204T | ||
| M101 | 8 | C41T, C43T, G96A, C99A, C105T, G166A, G224A, C228T | ||
| M119 | 8 | G68A, G77C, C99G, A104T, G108A, A207T, G224A, G207A | ||
| M64 | 9 | C78T, G83C, G96A, C120T, C123T, C125T, G175A, G224A, G227A | ||
| M82 | 14 | G71C, G73C, C78T, C80T, G96A, C99G, A104T, C123T, C126T, A133T, G134T, A217T, G224A, G227A |
Total = 22 clones (10,252 bp); 135 mutations; 1.3% mutations/bp.
Mutations are listed with the first letter representing the germline nucleotide, the number depicting the position of the mutation as shown in Fig. 2, and the second letter signifying the mutant nucleotide. Negative numbers correspond to mutations in the 5′ intron (17). Tandem mutations are underlined.