Rockefeller University Press

Table 1

Extent of the Pulmonary Inflammatory Process of TCR-transgenic Mice Infected with Influenza A Virus

Mice	Virus	Time after infection
Mice	Virus	Day 2	Day 5	Day 8	Day 15	Day 20
F5–RAG-1^−/−	A/NT/60/68, 10⁷ PFU	+	++	++	^*
	A/NT/60/68, 10² PFU	−	+	+	±	±
	X31, 10⁷ PFU	+	++	++	^*
RAG-1^−/−	A/NT/60/68, 10⁷ PFU	±	+	++	++	++
	X31, 10⁷ PFU	+	++	++	^*

Mice	Virus	Time after infection
Mice	Virus	Day 2	Day 5	Day 8	Day 15	Day 20
F5–RAG-1^−/−	A/NT/60/68, 10⁷ PFU	+	++	++	^*
	A/NT/60/68, 10² PFU	−	+	+	±	±
	X31, 10⁷ PFU	+	++	++	^*
RAG-1^−/−	A/NT/60/68, 10⁷ PFU	±	+	++	++	++
	X31, 10⁷ PFU	+	++	++	^*

++, Intensive pathology with cell inflammation encompassing several segments of lung tissues. Development of extensive lung edema and congestion. Thickened intraalveolar septa and loss of alveoli. +, Inflammatory reaction consisting of a few foci of peribronchiolar and perivascular infiltrates on medium and small airways. There was modest evidence of epithelial necrosis of affected tracheobronchiolar mucosa. ±, Lung tissue with a few infiltrates. No epithelial necrosis or desquamation. −, Lung tissue well aerated. No infiltrates or pathologic alteration of lung tissue.

, At the indicated time, all mice had died.

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