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Table 3

The Amino Acid Sequences of the CDR3 Regions from CTL Lines or Clones Derived from Chronically Infected HIV Patients

Patient		Specificity		TCR BV chain of CTL line/clone										TCR In PBL
Patient		Specificity		BV				CDR3				BJ		1996				1998
868		A2-Gag^*		5S2		CAS		SDTVSYEQY		FG		2S7		7/15^‡		3.62^§		4/9^‡		4.18^§
		B27-Gag		5S2		CAS		TGSQPQSYEQY		FG		2S7		0/15		3.62		1/9		4.18
003		A2-Gag^*		5S1		CAS		SFDSGNSPLH		FG		1S6		N/D		N/D		7/14		2.63
		A2-Gag		8		CAS		SSDRSDQPQH		FG		1S5		12/12		17.5		4/15		7.5
065		A2-Pol		3		CAS		SFVVSPDTQY		FG		1S1		N/D		3.31		3/9		3.97

Patient		Specificity		TCR BV chain of CTL line/clone										TCR In PBL
Patient		Specificity		BV				CDR3				BJ		1996				1998
868		A2-Gag^*		5S2		CAS		SDTVSYEQY		FG		2S7		7/15^‡		3.62^§		4/9^‡		4.18^§
		B27-Gag		5S2		CAS		TGSQPQSYEQY		FG		2S7		0/15		3.62		1/9		4.18
003		A2-Gag^*		5S1		CAS		SFDSGNSPLH		FG		1S6		N/D		N/D		7/14		2.63
		A2-Gag		8		CAS		SSDRSDQPQH		FG		1S5		12/12		17.5		4/15		7.5
065		A2-Pol		3		CAS		SFVVSPDTQY		FG		1S1		N/D		3.31		3/9		3.97

Designates a CTL clone.

The transcript frequency of the frequency of the CTL clonotype present in the PBL of each patient in 1996 and 1998.

Percentage of CD8⁺ T cells stained with mAbs specific for the human TCR BV chains is shown.