Table I

. | . | Haplotype . | . | Number . | . | Fold induction^{*}
. | . | Range . |
---|---|---|---|---|---|---|---|---|

IL-1Ra | ||||||||

A2^{−} | 5 | 5.7 | 1.7–8.6 | |||||

A2^{+} | 8 | 10.0 | 2.6–29.5 | |||||

IL-1β (−511) | ||||||||

A2^{−} | 3 | 25.9 | 11.3–51.0 | |||||

A2^{+} | 10 | 46.5 | 23.7–84.7 | |||||

IL-1β (+3953) | ||||||||

A2^{−} | 7 | 52.3 | 15.5–84.7 | |||||

A2^{+} | 6 | 29.3 | 11.3–47.5 |

. | . | Haplotype . | . | Number . | . | Fold induction^{*}
. | . | Range . |
---|---|---|---|---|---|---|---|---|

IL-1Ra | ||||||||

A2^{−} | 5 | 5.7 | 1.7–8.6 | |||||

A2^{+} | 8 | 10.0 | 2.6–29.5 | |||||

IL-1β (−511) | ||||||||

A2^{−} | 3 | 25.9 | 11.3–51.0 | |||||

A2^{+} | 10 | 46.5 | 23.7–84.7 | |||||

IL-1β (+3953) | ||||||||

A2^{−} | 7 | 52.3 | 15.5–84.7 | |||||

A2^{+} | 6 | 29.3 | 11.3–47.5 |

Freshly isolated monocytes from 13 donors of differing genotypes were rested overnight and then stimulated for 4 h with *M. tuberculosis* at 1:1. Cytokine gene expression was quantitated by hybridization of 2 μg of the resultant RNA to [^{32}P]UTP-labeled complimentary RNA probes, including L32 and GAPDH as constitutively expressed “housekeeping” genes. The *M. tuberculosis*–induced fold increase in IL-1Ra or IL-1β gene expression was calculated by dividing the band density in the presence of *M. tuberculosis* by the density in its absence.

*

*P* values were 0.30 for IL-1Ra, 0.14 for IL-1β (−511), and 0.04 for IL-1β (+3953).

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