Effect of Aminoguanidine Treatment in X-CGD Mice
| Wk after infection . | . | AG . | . | Parasite burden . | . | Percentage of infected foci showing granuloma formation . |
|---|---|---|---|---|---|---|
| LDU | ||||||
| 2 | − | 3,065 ± 173 | 37 ± 5 | |||
| + | 5,214 ± 251* | 9 ± 2* | ||||
| 4 | − | 810 ± 146 | 88 ± 10 | |||
| + | 2,550 ± 128* | 93 ± 8 |
| Wk after infection . | . | AG . | . | Parasite burden . | . | Percentage of infected foci showing granuloma formation . |
|---|---|---|---|---|---|---|
| LDU | ||||||
| 2 | − | 3,065 ± 173 | 37 ± 5 | |||
| + | 5,214 ± 251* | 9 ± 2* | ||||
| 4 | − | 810 ± 146 | 88 ± 10 | |||
| + | 2,550 ± 128* | 93 ± 8 |
Starting 1 d after L. donovani infection, X-CGD mice received acidified drinking water alone or the same water containing AG at 1% (wt/vol) for 4 wk. Results indicate mean ± SEM values from two experiments, and for liver parasite burdens represent eight mice per group and for granuloma formation (percentage of liver-infected foci showing developing or mature granulomas; see Table II) represent six mice per group.
Significantly different (P < 0.05) from control mice.