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Table 2

Effect of Injections of VEGFR-1/Fc Chimeric Protein on the Survival of rhM-CSF–recruited Osteoclasts in op/op Mice

TreatmentNo. of osteoclasts/section
 (mean ± SD) 
None 59 ± 9 
VEGFR-1Fc 15 ± 5 
Human IgG1 65 ± 9 
VEGFR-1/Fc and rhM-CSF 87 ± 9 
rhM-CSF 81 ± 8 
TreatmentNo. of osteoclasts/section
 (mean ± SD) 
None 59 ± 9 
VEGFR-1Fc 15 ± 5 
Human IgG1 65 ± 9 
VEGFR-1/Fc and rhM-CSF 87 ± 9 
rhM-CSF 81 ± 8 

op/op mice were pretreated with a single injection of 5 μg rhM/CSF at 12 d of age. 5 μg each of VEGFR-1/Fc and/or rhM-CSF or 5 μg human IgG1 was consecutively injected six times at 12-h intervals into the mice during 16–18 d of age. Osteoclasts in the longitudinal sections of the median portion of whole femurs were counted. Results represent the mean ± SD of six sections from three mice.

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