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Table 3

Effect of VEGFR-1/Fc Injection on Osteoclast Recruitment by rhM-CSF in op/op Mice

TreatmentNo. of injectionsNo. of osteoclasts/section
  (mean ± SD) 
None 3 ± 2 
rhM-CSF 56 ± 9 
rhM-CSF 108 ± 11 
rhM-CSF and VEGFR-1/Fc 101 ± 7 
TreatmentNo. of injectionsNo. of osteoclasts/section
  (mean ± SD) 
None 3 ± 2 
rhM-CSF 56 ± 9 
rhM-CSF 108 ± 11 
rhM-CSF and VEGFR-1/Fc 101 ± 7 

The treatments of op/op mice began at 12 d of age. They received either a single injection of 5 μg rhM-CSF or six consecutive injections of 5 μg rhM-CSF alone or together with 5 μg VEGFR-1/Fc at 12-h intervals, and were killed at 3 d after the onset of the treatments. Osteoclasts in the longitudinal sections of the median portion of whole femurs were counted. Results represent the mean ± SD of six sections from three mice.

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