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Table 2

EAE in Wild-type and B7-1/B7-2−/− Mice Induced by Adoptive Transfer of Wild-type MOG-specific T Cells

Clinical EAEHistological EAE
IncidenceDay of onsetMean maximal scoreDuration (d)IncidenceMeningeal fociParenchymal fociTotal foci
  mean ± SE mean ± SE mean ± SE  mean ± SE mean ± SE mean ± SE 
Wild-type 10/16    14/16    
 (62.5%) 12.0 ± 0.8 2.5 ± 0.2 19.0 ± 1.0 (87.5%) 40.3 ± 9.0 32.9 ± 8.9 76.3 ± 9.4 
B7-1/B7-2−/− 8/13 16.0 ± 1.7 1.3 ± 0.1 8.5 ± 1.5 11/13 11.4 ± 3.3 2.2 ± 0.7 13.6 ± 3.8 
 (61.5%) P < 0.05 P < 0.001 P < 0.001 (84.6%) P < 0.001 P < 0.01 P < 0.001 
Clinical EAEHistological EAE
IncidenceDay of onsetMean maximal scoreDuration (d)IncidenceMeningeal fociParenchymal fociTotal foci
  mean ± SE mean ± SE mean ± SE  mean ± SE mean ± SE mean ± SE 
Wild-type 10/16    14/16    
 (62.5%) 12.0 ± 0.8 2.5 ± 0.2 19.0 ± 1.0 (87.5%) 40.3 ± 9.0 32.9 ± 8.9 76.3 ± 9.4 
B7-1/B7-2−/− 8/13 16.0 ± 1.7 1.3 ± 0.1 8.5 ± 1.5 11/13 11.4 ± 3.3 2.2 ± 0.7 13.6 ± 3.8 
 (61.5%) P < 0.05 P < 0.001 P < 0.001 (84.6%) P < 0.001 P < 0.01 P < 0.001 
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