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Table 1

PIM1 Compensates for the Lack of Cytokine and Pre-TCR Signaling

GenotypeNo. mice analyzedNo. thymocytes
   ×10−6 
wt 200–300 
wt + Bcl2 150–250 
wt + LckF 200–300 
wt + Pim1 250–350 
γc−/− 10–25 
γc−/− + Bcl2 10–20 
γc−/− + LckF 5–15 
γc−/− + Pim1 70–100 
γc−/− + Bcl2, LckF 5–20 
IL-7−/− 10–25 
IL-7−/− + Pim1 70–100 
CD3γ2/− 1–2 
CD3γ2/− + Pim1 1–2 
CD3γ2/− + LckF 110–200 (5–8 wk old) 
Rag2−/− 1–3 
Rag2−/− + Pim1 150–250 (8–9 wk old) 
Rag2−/− + Pim1 5–15 (4–5 wk old) 
GenotypeNo. mice analyzedNo. thymocytes
   ×10−6 
wt 200–300 
wt + Bcl2 150–250 
wt + LckF 200–300 
wt + Pim1 250–350 
γc−/− 10–25 
γc−/− + Bcl2 10–20 
γc−/− + LckF 5–15 
γc−/− + Pim1 70–100 
γc−/− + Bcl2, LckF 5–20 
IL-7−/− 10–25 
IL-7−/− + Pim1 70–100 
CD3γ2/− 1–2 
CD3γ2/− + Pim1 1–2 
CD3γ2/− + LckF 110–200 (5–8 wk old) 
Rag2−/− 1–3 
Rag2−/− + Pim1 150–250 (8–9 wk old) 
Rag2−/− + Pim1 5–15 (4–5 wk old) 
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