The Influence of IL-4 on the Production of IL-12 p70 and p40 In Vivo
Stimulus
.
p70
.
p40
.
pg/ml
ng/ml
None (medium alone)
<60
4 ± 1
LPS
127 ± 23
162 ± 15
LPS + IL-4
254 ± 73
74 ± 4
CpG
693 ± 150
369 ± 10
CpG + IL-4
2,132 ± 47
226 ± 35
Stimulus
.
p70
.
p40
.
pg/ml
ng/ml
None (medium alone)
<60
4 ± 1
LPS
127 ± 23
162 ± 15
LPS + IL-4
254 ± 73
74 ± 4
CpG
693 ± 150
369 ± 10
CpG + IL-4
2,132 ± 47
226 ± 35
Mice were injected with the stimulus, killed 4 h later, then serum levels of p40 and p70 IL-12 were determined by ELISA. This experiment was repeated three times with similar results.