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Table 1

Activated/Memory Phenotypes of CNS and Splenic T Cells from Older (>10 wk) TCR Transgenic and Nontransgenic Mice

Percentage ofnaivePercentage ofCD49d highPercentage ofCD44 highPercentage ofCD45RB low
CNSSpleenCNSSpleenCNSSpleenCNSSpleen
B10.PL 17.7 ± 7.9 51.7 ± 4.9 37.7 12.2 57.9 ± 11.1 26.8 ± 7.4 63.9 ± 5.8 32.9 ± 2.8 
NTG n = 9 n = 9 n = 1 n = 1 n = 10 n = 10 n = 11 n = 11 
MBP 6.8 ± 3.8 24.4 ± 11.1 ND ND 69.3 ± 15.2 31.7 ± 9.3 79 ± 6.5 63.6 ± 11.4 
TCR1 n =n =  n =n =n = 10 n = 10 
MBP 12.1 ± 0.7 38.8 ± 0.1 ND ND 39.5 ± 7 17.2 ±11 78.8 ± 8.6 49.9 ± 2.4 
TCR2 n =n =  n =n =n =n =
C57Bl/6 18.7 41.2 ND ND 62.7 36.4 65.3 34.4 
Ntg n =n =  n =n =n =n =
Rag−/− 84.4 84.6 8.3 ± 2.1 1 ± 1 19.3 ± 11.8 8.5 ± 1.7 7.7 9.8 
Ova n =n =n =n =n =n =n =n =
Percentage ofnaivePercentage ofCD49d highPercentage ofCD44 highPercentage ofCD45RB low
CNSSpleenCNSSpleenCNSSpleenCNSSpleen
B10.PL 17.7 ± 7.9 51.7 ± 4.9 37.7 12.2 57.9 ± 11.1 26.8 ± 7.4 63.9 ± 5.8 32.9 ± 2.8 
NTG n = 9 n = 9 n = 1 n = 1 n = 10 n = 10 n = 11 n = 11 
MBP 6.8 ± 3.8 24.4 ± 11.1 ND ND 69.3 ± 15.2 31.7 ± 9.3 79 ± 6.5 63.6 ± 11.4 
TCR1 n =n =  n =n =n = 10 n = 10 
MBP 12.1 ± 0.7 38.8 ± 0.1 ND ND 39.5 ± 7 17.2 ±11 78.8 ± 8.6 49.9 ± 2.4 
TCR2 n =n =  n =n =n =n =
C57Bl/6 18.7 41.2 ND ND 62.7 36.4 65.3 34.4 
Ntg n =n =  n =n =n =n =
Rag−/− 84.4 84.6 8.3 ± 2.1 1 ± 1 19.3 ± 11.8 8.5 ± 1.7 7.7 9.8 
Ova n =n =n =n =n =n =n =n =
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