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Table I.

Composition of Bone Marrow and Spleen in Control and mHEL+ Reconstituted Mice




Bone marrow

Spleen
Donor
Recipienta
Cellularityb
IgDa+c
HEL bindingc
Cellularityb
IgDa+c
HEL bindingc
(n)106106106106106106
Tg+ bim+/+ Control (4) 14.9 ± 2.5 1.2 ± 0.3 1.1 ± 0.4 17.8 ± 5.6 10.8 ± 3.5 10.4 ± 3.5 
 mHEL+ (8) 10.3 ± 2.3 0.5 ± 0.2d 0.4 ± 0.1e 8.1 ± 6.1 0.3 ± 0.2f 0.01 ± 0.03 
Tg+ bim−/− Control (4) 15.5 ± 3.0 4.0 ± 0.6 3.6 ± 0.5 83.5 ± 68.3 66.1 ± 58.7 63.6 ± 57.3 

 
mHEL+ (8)
 
11.4 ± 3.2
 
1.1 ± 0.5d
 
0.9 ± 0.3e
 
20.6 ± 11.9
 
1.7 ± 0.9f
 
0.07 ± 0.1
 



Bone marrow

Spleen
Donor
Recipienta
Cellularityb
IgDa+c
HEL bindingc
Cellularityb
IgDa+c
HEL bindingc
(n)106106106106106106
Tg+ bim+/+ Control (4) 14.9 ± 2.5 1.2 ± 0.3 1.1 ± 0.4 17.8 ± 5.6 10.8 ± 3.5 10.4 ± 3.5 
 mHEL+ (8) 10.3 ± 2.3 0.5 ± 0.2d 0.4 ± 0.1e 8.1 ± 6.1 0.3 ± 0.2f 0.01 ± 0.03 
Tg+ bim−/− Control (4) 15.5 ± 3.0 4.0 ± 0.6 3.6 ± 0.5 83.5 ± 68.3 66.1 ± 58.7 63.6 ± 57.3 

 
mHEL+ (8)
 
11.4 ± 3.2
 
1.1 ± 0.5d
 
0.9 ± 0.3e
 
20.6 ± 11.9
 
1.7 ± 0.9f
 
0.07 ± 0.1
 
a

Recipient mice were C57BL/6 (control) or C57BL/6 mHEL transgene positive.

b

Cellularity was determined by viable counts after red cell removal and are given per femur and per spleen.

c

IgDa and HEL-binding cell counts are based on the proportion of cells staining positive by flow cytometry immediately ex vivo and whole organ cell counts.

d

P = 0.01.

e

P < 0.001.

f

P = 0.001.

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