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Table III.

Persistence of Bim-deficient HEL-binding B Cells in the Presence of Soluble Self-antigen


Donora

Recipientb

Cellularityc

IgDa+

IgDa+d

HEL bindingd

(n)
106
% of organ
106
106
Tg+ bim+/+ Control (3) 29.3 ± 9.5 55.9 ± 2.3 16.4 ± 5.6 15.0 ± 4.7 
 sHEL+ (3) 8.1 ± 3.1 17.3 ± 7.5 1.4 ± 0.9e 1.2 ± 0.9f 
Tg+ bim−/− Control (3) 51.5 ± 17.3 51.8 ± 12.3 26.7 ± 14.6 23.3 ± 14.7 

 
sHEL+ (3)
 
86.7 ± 54.3
 
29.3 ± 11.4
 
25.4 ± 13.8e
 
20.2 ± 13.9f
 

Donora

Recipientb

Cellularityc

IgDa+

IgDa+d

HEL bindingd

(n)
106
% of organ
106
106
Tg+ bim+/+ Control (3) 29.3 ± 9.5 55.9 ± 2.3 16.4 ± 5.6 15.0 ± 4.7 
 sHEL+ (3) 8.1 ± 3.1 17.3 ± 7.5 1.4 ± 0.9e 1.2 ± 0.9f 
Tg+ bim−/− Control (3) 51.5 ± 17.3 51.8 ± 12.3 26.7 ± 14.6 23.3 ± 14.7 

 
sHEL+ (3)
 
86.7 ± 54.3
 
29.3 ± 11.4
 
25.4 ± 13.8e
 
20.2 ± 13.9f
 
a

Genotype of bone marrow donor used in original reconstitution.

b

Recipients were either C57Bl/6 (control) or C57Bl/6 sHEL transgene positive.

c

Cellularity is as defined in Table I.

d

IgDa and HEL-binding counts are as determined for Table I.

e

P < 0.05.

f

P = 0.07.

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