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Table I.

Cellular Subset Distribution in Different Chimeric and BAFF−/− Mice




WT→KO

KO→WT

WT→WT

KO
Total 35.21 ± 4.95a 91.75 ± 10.9b 86.76 ± 5.98b 44.50 ± 9.32a 
B220+ 14.28 ± 1.78a 64.26 ± 5.01b 50.15 ± 4.06b 8.65 ± 0.78a 
CD4+ and CD8+ 16.47 ± 2.40 25.82 ± 2.52 23.94 ± 1.60 21.93 ± 2.13 
CD11c+ 0.54 ± 0.10a 1.30 ± 0.25b 1.16 ± 0.15b 0.44 ± 0.02a 
CD11b+ 2.10 ± 0.66 1.78 ± 0.22 1.70 ± 0.17 1.52 ± 0.26 
FO (CD21interm CD23high8.04 ± 1.03a,b 45.45 ± 3.82b 38.93 ± 4.18b 1.70 ± 0.39a 
MZ (CD21high CD23low0.41 ± 0.12a 3.41 ± 0.42b 3.68 ± 0.37b 0.14 ± 0.04a 
NF (CD21 CD23)
 
2.89 ± 0.53a
 
10.79 ± 1.87
 
4.99 ± 0.56
 
4.58 ± 1.55
 



WT→KO

KO→WT

WT→WT

KO
Total 35.21 ± 4.95a 91.75 ± 10.9b 86.76 ± 5.98b 44.50 ± 9.32a 
B220+ 14.28 ± 1.78a 64.26 ± 5.01b 50.15 ± 4.06b 8.65 ± 0.78a 
CD4+ and CD8+ 16.47 ± 2.40 25.82 ± 2.52 23.94 ± 1.60 21.93 ± 2.13 
CD11c+ 0.54 ± 0.10a 1.30 ± 0.25b 1.16 ± 0.15b 0.44 ± 0.02a 
CD11b+ 2.10 ± 0.66 1.78 ± 0.22 1.70 ± 0.17 1.52 ± 0.26 
FO (CD21interm CD23high8.04 ± 1.03a,b 45.45 ± 3.82b 38.93 ± 4.18b 1.70 ± 0.39a 
MZ (CD21high CD23low0.41 ± 0.12a 3.41 ± 0.42b 3.68 ± 0.37b 0.14 ± 0.04a 
NF (CD21 CD23)
 
2.89 ± 0.53a
 
10.79 ± 1.87
 
4.99 ± 0.56
 
4.58 ± 1.55
 
a

Significantly (P < 0.01) different from the WT→WT mice.

b

Significantly (P < 0.01) different from the KO mice.

8–12 wk after the reconstitution of lethally irradiated (950 rads) mice with the BM, spleen cells were analyzed by FACS®. Mean cell numbers ×106 ± SD for each population are derived from 8–14 mice per group.

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