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Table I.

Nonepitope, nonenvelope changes frequently result in modal residuea


Siteb

Region

Subject

Change during acute infection
 (t0 t6)c

Subtype 1ad

Change relative to modal residuee
core 11 N → K K102Y2 toward 
88 core 17 S → N N128 toward 
840 NS2 21 S → G S10A1 away 
856 NS2 17 L → Q Q6H2L1 toward 
859 NS2 21 V → E V9 away 
861 NS2 21 V → I V7I1F1 away 
899 NS2 17 F → L L9 toward 
908 NS2 13 K → R K9 away 
945 NS2 12 T → A T9 away 
1021 NS2 12 K → E K9 away 
1113 NS3 17 T → A A73T1P1V1 toward 
1278 NS3 18 I → L I78S1 away 
1314 NS3 12 V → I I49F1 toward 
1338 NS3 18 S → T T46 toward 
1600 NS3 21 P → L P50L1 away 
1648
 
NS3
 
28
 
G → C
 
C54Y1
 
toward
 

Siteb

Region

Subject

Change during acute infection
 (t0 t6)c

Subtype 1ad

Change relative to modal residuee
core 11 N → K K102Y2 toward 
88 core 17 S → N N128 toward 
840 NS2 21 S → G S10A1 away 
856 NS2 17 L → Q Q6H2L1 toward 
859 NS2 21 V → E V9 away 
861 NS2 21 V → I V7I1F1 away 
899 NS2 17 F → L L9 toward 
908 NS2 13 K → R K9 away 
945 NS2 12 T → A T9 away 
1021 NS2 12 K → E K9 away 
1113 NS3 17 T → A A73T1P1V1 toward 
1278 NS3 18 I → L I78S1 away 
1314 NS3 12 V → I I49F1 toward 
1338 NS3 18 S → T T46 toward 
1600 NS3 21 P → L P50L1 away 
1648
 
NS3
 
28
 
G → C
 
C54Y1
 
toward
 
a

Changes that were not located in demonstrated epitopes and not located in the envelope region (Fig. 2).

b

Position in H77 polyprotein (GenBank/EMBL/DDBJ accession no. AF009606).

c

Amino acids inferred from cDNA clones obtained at t0 and t6, respectively. Changes were only inferred when independent cDNA clone sequences were in agreement. Underlined residues match modal (most frequently observed) residue in the next column.

d

Subscripts indicate number of HCV subtype 1a sequences in the Los Alamos National Laboratory database with the indicated amino acid at that position.

e

Toward, change is from nonmodal residue to modal residue; away, change is from modal residue to nonmodal residue.

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