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Table II.

Observed versus expecteda frequencies of change to modal residue at 16 sites not located in epitopes nor in envelope (E1 or E2) genes




Expected

Observed
Change to modal residue 16b (1/19) = 0.8 ≈ 1 8b 
Change to nonmodal residue
 
16b (18/19) = 15.2 ≈ 15
 
8
 



Expected

Observed
Change to modal residue 16b (1/19) = 0.8 ≈ 1 8b 
Change to nonmodal residue
 
16b (18/19) = 15.2 ≈ 15
 
8
 
a

Based on the null hypothesis that all amino acids are equally likely at each position.

b

P = 0.015.

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