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Table I.

T cell lineage precursor frequency in early stages of T cell development isolated from CD45.1+ newborn donor thymic lobes either 4 or 6 d after transplantation under the kidney capsule of CCR9EGFP/+//CD45.1/CD45.2 F1 recipient mice

T cell progenitor frequency−1 (95% confidence interval)
Time of sorting
 after transplantation
Sorted cell type
CD45.2+ CCR9EGFP+
 (recipient-derived)
CD45.2− CCR9EGFP−
 (donor-derived)
Day 4 EGFP-pos ETPa 24.5 (5.8–103.7) 5.4 (2.6–11.6) 
 ETP 43.5 (10.6–176.8) 2.5 (1.6–4) 
 DN1c ∞ 17.5 (2.4–129.3) 
 DN1d ∞ ∞ 
 DN1e ∞ 1,323 (320–5,481) 
 CLP-2 ∞ ∞ 
 CTP ∞ 168 (40.5–698) 
Day 6 EGFP-pos ETP 5.9 (3.8–9.2) ∞ 
 ETP 22.2 (14.2–34.5) 28 (17.2–45.6) 
 DN1c ∞ 37.7 (12.1–117.5) 
 DN1d ∞ 439 (107–1,800) 
 DN1e ∞ ∞ 
 CLP-2 ∞ 58.8 (25.4–135.9) 
 CTP ∞ ∞ 
T cell progenitor frequency−1 (95% confidence interval)
Time of sorting
 after transplantation
Sorted cell type
CD45.2+ CCR9EGFP+
 (recipient-derived)
CD45.2− CCR9EGFP−
 (donor-derived)
Day 4 EGFP-pos ETPa 24.5 (5.8–103.7) 5.4 (2.6–11.6) 
 ETP 43.5 (10.6–176.8) 2.5 (1.6–4) 
 DN1c ∞ 17.5 (2.4–129.3) 
 DN1d ∞ ∞ 
 DN1e ∞ 1,323 (320–5,481) 
 CLP-2 ∞ ∞ 
 CTP ∞ 168 (40.5–698) 
Day 6 EGFP-pos ETP 5.9 (3.8–9.2) ∞ 
 ETP 22.2 (14.2–34.5) 28 (17.2–45.6) 
 DN1c ∞ 37.7 (12.1–117.5) 
 DN1d ∞ 439 (107–1,800) 
 DN1e ∞ ∞ 
 CLP-2 ∞ 58.8 (25.4–135.9) 
 CTP ∞ ∞ 
a

4 d after transplantation, the vast majority of ETPs are donor derived, and a defined EGFP+-recipient ETP population that can be gated for is not discernible.

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