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Table 1.

Characteristics of CD27 and CD27+ B cells in STAT3-deficient individuals

Parameter CD27 B cells CD27+ B cells 
 Normal STAT3MUT Normal STAT3MUT 
% Cells 75.2 ± 2.7 94.9 ± 0.77 24.8 ± 2.7 5.1 ± 0.77 
% IgM+ 87.0 ± 2.2 90.0 ± 2.0 47 ± 3.8 48 ± 3.1 
% IgD+ 88.0 ± 1.9 93.0 ± 1.8 41 ± 2.2 45 ± 2.0 
% IgG+ 3.2 ± 0.45 1.6 ± 0.6a 25 ± 2.1 32 ± 2.8a 
% IgG1+ (% total IgG+ cells) 2.3 ± 1.0 (62.1) 0.63 ± 0.24 (40.1) 11 ± 1.7 (51.4) 22 ± 2.8 (72.7)b 
% IgG2+ (% total IgG+ cells) 0.72 ± 0.14 (19.4) 0.54 ± 0.1 (34.4) 6.7 ± 2.1 (31.3) 3.9 ± 0.9 (12.9) 
% IgG3+ (% total IgG+ cells) 0.62 ± 0.15 (16.7) 0.36 ± 0.12 (22.9) 3.6 ± 0.9 (16.8) 4.1 ± 1.1 (13.5) 
% IgG4+ (% total IgG+ cells) 0.065 ± 0.02 (1.8) 0.04 ± 0.014 (2.5) 0.11 ± 0.04 (0.5) 0.27 ± 0.08 (0.9) 
% IgA+ 1.2 ± 0.2 0.64 ± 0.15a 17 ± 1.2 8.6 ± 1.1c 
% CD23+ 62.0 ± 3.9 86.0 ± 3.7c 18 ± 3.9 46 ± 4.7c 
Parameter CD27 B cells CD27+ B cells 
 Normal STAT3MUT Normal STAT3MUT 
% Cells 75.2 ± 2.7 94.9 ± 0.77 24.8 ± 2.7 5.1 ± 0.77 
% IgM+ 87.0 ± 2.2 90.0 ± 2.0 47 ± 3.8 48 ± 3.1 
% IgD+ 88.0 ± 1.9 93.0 ± 1.8 41 ± 2.2 45 ± 2.0 
% IgG+ 3.2 ± 0.45 1.6 ± 0.6a 25 ± 2.1 32 ± 2.8a 
% IgG1+ (% total IgG+ cells) 2.3 ± 1.0 (62.1) 0.63 ± 0.24 (40.1) 11 ± 1.7 (51.4) 22 ± 2.8 (72.7)b 
% IgG2+ (% total IgG+ cells) 0.72 ± 0.14 (19.4) 0.54 ± 0.1 (34.4) 6.7 ± 2.1 (31.3) 3.9 ± 0.9 (12.9) 
% IgG3+ (% total IgG+ cells) 0.62 ± 0.15 (16.7) 0.36 ± 0.12 (22.9) 3.6 ± 0.9 (16.8) 4.1 ± 1.1 (13.5) 
% IgG4+ (% total IgG+ cells) 0.065 ± 0.02 (1.8) 0.04 ± 0.014 (2.5) 0.11 ± 0.04 (0.5) 0.27 ± 0.08 (0.9) 
% IgA+ 1.2 ± 0.2 0.64 ± 0.15a 17 ± 1.2 8.6 ± 1.1c 
% CD23+ 62.0 ± 3.9 86.0 ± 3.7c 18 ± 3.9 46 ± 4.7c 

Values represent percentage (or absolute number for CD4+CXCR5+ T cells) of cells expressing the indicated surface molecule; each value represents the mean ± SEM; normal donors: n = 8–24; STAT3 patients: n = 9–27. P-values were determined by Student’s t test, comparing normal with STAT3MUT B cells.

a

P < 0.05.

b

P < 0.01.

c

P < 0.001.

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