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Table 1.

Prnp KO mouse lines analyzed in this study

Prnp KO mouse line	ES cells	Origin of ES cells	Strain of partner of chimeric mouse	Location of colony	Reference
Prnp^ZrchI/ZrchI	AB1	129S7/SvEvBrd	B6	Zurich, Switzerland	Büeler et al. (1992)
Prnp^Ngsk/Ngsk	J1	129S4/SvJae	B6	Nagasaki, Japan	Sakaguchi et al. (1995)
Prnp^Edbg/Edbg	E14	129/Ola	129/Ola	Edinburgh, Scotland, UK	Manson et al. (1994)
Prnp^GFP/GFP	HM-1	129/Ola	B6	Cambridge, MA	Heikenwalder et al. (2008)
Prnp^Rkn/Rkn	E14	129P2/OlaHsd	B6	Wako-shi, Japan	Yokoyama et al. (2001)
Prnp^{ZrchII/ZrchII}	E14.1	129/OlaHsd	B6	Zurich, Switzerland	Rossi et al. (2001)
Prnp^Rcm0/Rcm0	HM-1	129/Ola	129/Ola	Edinburgh, Scotland, UK	Moore et al. (1995)

Prnp KO mouse line	ES cells	Origin of ES cells	Strain of partner of chimeric mouse	Location of colony	Reference
Prnp^ZrchI/ZrchI	AB1	129S7/SvEvBrd	B6	Zurich, Switzerland	Büeler et al. (1992)
Prnp^Ngsk/Ngsk	J1	129S4/SvJae	B6	Nagasaki, Japan	Sakaguchi et al. (1995)
Prnp^Edbg/Edbg	E14	129/Ola	129/Ola	Edinburgh, Scotland, UK	Manson et al. (1994)
Prnp^GFP/GFP	HM-1	129/Ola	B6	Cambridge, MA	Heikenwalder et al. (2008)
Prnp^Rkn/Rkn	E14	129P2/OlaHsd	B6	Wako-shi, Japan	Yokoyama et al. (2001)
Prnp^{ZrchII/ZrchII}	E14.1	129/OlaHsd	B6	Zurich, Switzerland	Rossi et al. (2001)
Prnp^Rcm0/Rcm0	HM-1	129/Ola	129/Ola	Edinburgh, Scotland, UK	Moore et al. (1995)

The present study is based on the analysis of mice carrying seven independently generated Prnp-null alleles. Prnp^Edbg/Edbg and Prnp^Rcm0/Rcm0 were always crossed to isogenic 129/Ola mice, whereas all other Prnp^−/− mice were crossed to B6 mice and then kept on a mixed B6 and 129 background or further backcrossed to B6 or other strains.

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