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Table 2.
T, B, and NK cell subsets in CD70-deficient individuals
Lymphocyte populationHealthy controlsHeterozygous relativesP1P2P3P4
CD4+ T cells (% of lymphocytes) 51.1 ± 5.2 38.4 ± 4.1 33.9↓ 47.3 33.7↓ 29.8↓ 
Percentage of CD4+ T cells       
Naive CD4+ T cells 44.4 ± 3.4 52.7 ± 6.6 64.3↑ 62.4↑ 59.1↑ 81.4↑ 
Stem cell memory 3.1 ± 0.3 1.6 ± 0.5 2.5 4↑ 0.28↓ 0.73↓ 
Central memory 28.3 ± 3.4 17.6 ± 5.4 15.3↓ 9.8↓ 20.1↓ 10.8↓ 
Effector memory 20 ± 2.7 25 ± 6 14.8 22.4 10.7↓ 5.4↓ 
Tfh cells 7 ± 1.1 9.8 ± 7.1 3.6↓ 12.5↑ 23.9↑ NA 
Regulatory T cells 6.1 ± 1.1 5.9 ± 0.5 7.4 6.4 5.8 NA 
CD8+ T cells (% of lymphocytes) 22.1 ± 3 14.2 ± 1.3 31.8↑ 14.5↓ 35.6↑ 19.8 
Percentage of CD8+ T cells       
Naive CD8+ T cells 27.8 ± 3.4 44.2 ± 4.6 46.9↑ 45↑ 48.4↑ 53.3↑ 
Stem cell memory 2.3 ± 0.5 5.8 ± 2.7 1.2↓ 2.9 5↑ 6.5↑ 
Central memory 9.4 ± 1.6 8.7 ± 2.9 2.1↓ 3.2↓ 4.5↓ 17.1↑ 
Effector memory 36.3 ± 2.4 25.6 ± 3.1 9.8↓ 17.7↓ 30.8↓ 16↓ 
TEMRA 23.5 ± 3.8 14.6 ± 3.8 39.9↑ 29.8 11.3↓ 7↓ 
B cells (% of lymphocytes) 9.7 ± 1.7 21.8 ± 5 10.7 2.6↓ 24.2↑ NA 
Percentage of B cells       
Transitional 4.9 ± 0.5 3.6 ± 1 10.8↑ 10.5↑ 9.2↑ NA 
Naive 68 ± 7 70.2 ± 17.5 82.1↑ 68 85↑ NA 
Memory 25.1 ± 6.2 24 ± 17 6.3↓ 15.5 4.7↓ NA 
Switched memory (% of memory B cells) 54.3 ± 5.1 44.8 ± 23.8 27.4↓ 13↓ 13.4↓ NA 
NK cells (% of lymphocytes) 5.31 ± 0.6 15.8 ±19.7 4.2 5.2 2.9↓ 5.1 
Percentage of NK cells       
CD56bright 93 ± 1 96.1 ± 2.4 84.5↓ 91 86.3↓ 97.4 
CD56dim 6.6 ± 1 3.6 ± 2.2 14.1↑ 4.06↓ 13.7↑ 2.2↓ 
CD16+ 76.9 ± 2.4 89.5 ± 5.5 66.9↓ 88.5↑ 84.6↑ 87.5↑ 
CD27+ 20.5 ± 2 17.3 ± 4.8 20 23.8 18.8 18.7 
CD57+ 60.2 ± 2.4 78.8 ± 14.7 55.4 70.7↑ 54.9↓ 75.9↑ 
2B4+ 97.8 ± 0.4 97.5 ± 2.3 95.7↓ 97.1 98.8 96↓ 
CD94+ 54.2 ± 2.5 80 ± 15.9 37.7↓ 66.8↑ 79.2↑ 64.6↑ 
KLRG1+ 39.2 ± 5.8 60.6 ± 20.4 52.6↑ 62.7↑ 32 42.6 
NKp30+ 58.7 ± 5.8 27.8 ± 20 28.3↓ 32.7↓ 36.8↓ 63.9 
NKp44+ 8.7 ± 3.7 4.4 ± 0.5 7.2 25.4↑ 4.3 12 
NKp46+ 31.5 ± 6.1 15 ± 11.3 26.6 26.7 37.5 45.4↑ 
Lymphocyte populationHealthy controlsHeterozygous relativesP1P2P3P4
CD4+ T cells (% of lymphocytes) 51.1 ± 5.2 38.4 ± 4.1 33.9↓ 47.3 33.7↓ 29.8↓ 
Percentage of CD4+ T cells       
Naive CD4+ T cells 44.4 ± 3.4 52.7 ± 6.6 64.3↑ 62.4↑ 59.1↑ 81.4↑ 
Stem cell memory 3.1 ± 0.3 1.6 ± 0.5 2.5 4↑ 0.28↓ 0.73↓ 
Central memory 28.3 ± 3.4 17.6 ± 5.4 15.3↓ 9.8↓ 20.1↓ 10.8↓ 
Effector memory 20 ± 2.7 25 ± 6 14.8 22.4 10.7↓ 5.4↓ 
Tfh cells 7 ± 1.1 9.8 ± 7.1 3.6↓ 12.5↑ 23.9↑ NA 
Regulatory T cells 6.1 ± 1.1 5.9 ± 0.5 7.4 6.4 5.8 NA 
CD8+ T cells (% of lymphocytes) 22.1 ± 3 14.2 ± 1.3 31.8↑ 14.5↓ 35.6↑ 19.8 
Percentage of CD8+ T cells       
Naive CD8+ T cells 27.8 ± 3.4 44.2 ± 4.6 46.9↑ 45↑ 48.4↑ 53.3↑ 
Stem cell memory 2.3 ± 0.5 5.8 ± 2.7 1.2↓ 2.9 5↑ 6.5↑ 
Central memory 9.4 ± 1.6 8.7 ± 2.9 2.1↓ 3.2↓ 4.5↓ 17.1↑ 
Effector memory 36.3 ± 2.4 25.6 ± 3.1 9.8↓ 17.7↓ 30.8↓ 16↓ 
TEMRA 23.5 ± 3.8 14.6 ± 3.8 39.9↑ 29.8 11.3↓ 7↓ 
B cells (% of lymphocytes) 9.7 ± 1.7 21.8 ± 5 10.7 2.6↓ 24.2↑ NA 
Percentage of B cells       
Transitional 4.9 ± 0.5 3.6 ± 1 10.8↑ 10.5↑ 9.2↑ NA 
Naive 68 ± 7 70.2 ± 17.5 82.1↑ 68 85↑ NA 
Memory 25.1 ± 6.2 24 ± 17 6.3↓ 15.5 4.7↓ NA 
Switched memory (% of memory B cells) 54.3 ± 5.1 44.8 ± 23.8 27.4↓ 13↓ 13.4↓ NA 
NK cells (% of lymphocytes) 5.31 ± 0.6 15.8 ±19.7 4.2 5.2 2.9↓ 5.1 
Percentage of NK cells       
CD56bright 93 ± 1 96.1 ± 2.4 84.5↓ 91 86.3↓ 97.4 
CD56dim 6.6 ± 1 3.6 ± 2.2 14.1↑ 4.06↓ 13.7↑ 2.2↓ 
CD16+ 76.9 ± 2.4 89.5 ± 5.5 66.9↓ 88.5↑ 84.6↑ 87.5↑ 
CD27+ 20.5 ± 2 17.3 ± 4.8 20 23.8 18.8 18.7 
CD57+ 60.2 ± 2.4 78.8 ± 14.7 55.4 70.7↑ 54.9↓ 75.9↑ 
2B4+ 97.8 ± 0.4 97.5 ± 2.3 95.7↓ 97.1 98.8 96↓ 
CD94+ 54.2 ± 2.5 80 ± 15.9 37.7↓ 66.8↑ 79.2↑ 64.6↑ 
KLRG1+ 39.2 ± 5.8 60.6 ± 20.4 52.6↑ 62.7↑ 32 42.6 
NKp30+ 58.7 ± 5.8 27.8 ± 20 28.3↓ 32.7↓ 36.8↓ 63.9 
NKp44+ 8.7 ± 3.7 4.4 ± 0.5 7.2 25.4↑ 4.3 12 
NKp46+ 31.5 ± 6.1 15 ± 11.3 26.6 26.7 37.5 45.4↑ 

The proportions and phenotype of the indicated lymphocyte subsets were determined as detailed in the B, T, and NK cell phenotyping section of Materials and methods. Subsets of cells were defined as follows: naive (CD45RA+CCR7+CD95), stem cell memory (CD45RA+CCR7+CD95+), central memory (CD45RACCR7+), effector memory (CD45RACCR7), and TEMRA (CD45RA+CCR7) CD4+ and CD8+ T cells; regulatory T cells (CD4+CD25hiCD127lo); T follicular cells (Tfh; CD4+CD45RACXCR5+); transitional (CD20+CD10+CD27), naive (CD20+CD10CD27), and memory (CD20+CD10CD27+) B cells; and class switched memory B cells (CD20+CD10CD27+IgMIgD). Values from patients that are above or below two SDs of average value of controls are in bold.

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