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Table I.

Inhibitory KIRs Induce Capture of Target Cell HLA-C


NK cell

Target cell

Number of conjugates imaged

Percentage of conjugates exhibiting clustering of GFP at the immune synapse

Percentage of conjugates showing transfer of GFP to NK cell
YTS/KIR2DL1 221/Cw6-GFP 415 66 49 (74) 
YTS/ECO 221/Cw6-GFP 207 
YTS/MOCK 221/Cw6-GFP 122 
CW4 YTS/KIR2DL1 221/CW4-GFP 20 80 65 (81) 
CW4-TMG YTS/KIR2DL1 221/CW6TMG-GFP 89 76 48 (63) 
YTS/KIR2DL1
 
221/Cw3-GFP
 
174
 
5
 
3
 

NK cell

Target cell

Number of conjugates imaged

Percentage of conjugates exhibiting clustering of GFP at the immune synapse

Percentage of conjugates showing transfer of GFP to NK cell
YTS/KIR2DL1 221/Cw6-GFP 415 66 49 (74) 
YTS/ECO 221/Cw6-GFP 207 
YTS/MOCK 221/Cw6-GFP 122 
CW4 YTS/KIR2DL1 221/CW4-GFP 20 80 65 (81) 
CW4-TMG YTS/KIR2DL1 221/CW6TMG-GFP 89 76 48 (63) 
YTS/KIR2DL1
 
221/Cw3-GFP
 
174
 
5
 
3
 

Various transfectants of 721.221 were imaged when conjugated to various YTS transfectants as listed. Table lists the percentage of cell conjugates for which GFP-tagged HLA-C clustered at the intercellular contact and the percentage of cell conjugates for which HLA-Cw6-GFP transferred to the NK cell. Numbers in parenthesis denote the percentage of those conjugates exhibiting clustering of GFP at the immune synapse that also show transfer of GFP into the NK cell.

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