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Table I.

Inflammatory Changes in Colon and Spleen after DSS Administration






Colon length

Colon weight/length ratio

Spleen weight
  cm mg/cm % body weight 
WT plus water 7.3 ± 0.2b&eb–e 35.9 ±1.7b&eb–e 0.31 ± 0.02b,e 
WT plus DSS 4.8 ± 0.2a,c 65.9 ± 3.5a,c 0.54 ± 0.04a,c 
iNOS−/− plus DSS 5.9 ± 0.2a,b,e 51.3 ± 2.1a,b 0.33 ± 0.02b,e 
p47phox−/− plus DSS 5.3 ± 0.1a 59.5 ± 4.8a 0.39 ± 0.05e 
SODTg plus DSS 4.7 ± 0.2a, c 62.6 ± 2.2a 0.65 ± 0.05a,c,d 
WT (conv.) plus DSS 5.2 ± 0.3 58.0 ± 4.6 0.51 ± 0.06 
iNOS−/−
 
plus DSS
 
6.4 ± 0.3f
 
45.4 ± 4.2f
 
0.30 ± 0.03f
 





Colon length

Colon weight/length ratio

Spleen weight
  cm mg/cm % body weight 
WT plus water 7.3 ± 0.2b&eb–e 35.9 ±1.7b&eb–e 0.31 ± 0.02b,e 
WT plus DSS 4.8 ± 0.2a,c 65.9 ± 3.5a,c 0.54 ± 0.04a,c 
iNOS−/− plus DSS 5.9 ± 0.2a,b,e 51.3 ± 2.1a,b 0.33 ± 0.02b,e 
p47phox−/− plus DSS 5.3 ± 0.1a 59.5 ± 4.8a 0.39 ± 0.05e 
SODTg plus DSS 4.7 ± 0.2a, c 62.6 ± 2.2a 0.65 ± 0.05a,c,d 
WT (conv.) plus DSS 5.2 ± 0.3 58.0 ± 4.6 0.51 ± 0.06 
iNOS−/−
 
plus DSS
 
6.4 ± 0.3f
 
45.4 ± 4.2f
 
0.30 ± 0.03f
 
a

P < 0.05 vs. WT plus water.

b

P < 0.05 vs. WT plus DSS.

c

P < 0.05 vs. iNO−/− + DSS.

d

P < 0.05 vs. p47phox−/− plus DSS.

e

P < 0.05 vs. SODTg plus DSS.

f

P < 0.05 vs. WT (conv.) plus DSS.

Colon and spleen changes after 7 d of oral treatment with either water in WT or DSS in WT, iNOS−/−, p47phox−/−, and SODTg mice (n = 9/group). In addition DSS-treated WT versus iNOS−/− mice under conventional housing conditions (n = 5/group). Mean ± SEM.

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