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Table II.

Histologic Alterations after DSS Administration




Total histology score

Crypt damage

Severity of colitis

Ulceratedsurface
  score score score 
WT plus DSS 17.9 ± 0.7b,d 6.7 ± 0.4b,d 7.4 ± 0.3b 20.3 ± 1.8b 
iNOS−/− plus DSS 12.0 ± 1.5a,d 4.4 ± 0.6a, d 4.7 ± 0.7a,d 7.4 ± 0.8a,c,d 
p47phox−/− plus DSS 16.3 ± 1.4d 6.9 ± 0.6d 6.1 ± 0.7d 15.9 ± 2.3b 
SODTg plus DSS 23.9 ± 1.3a&ca–c 10.4 ± 0.8a&ca–c 9.1 ± 0.5b,c 22.0 ± 2.0b 
WT (conv.) plus DSS 18.8 ± 1.6 7.1 ± 0.5 7.8 ± 0.5 22.8 ± 3.5 
iNOS−/− (conv.)
 
plus DSS
 
11.4 ± 2.0e
 
3.9 ± 1.7e
 
4.3 ± 0.9e
 
6.2 ± 2.7e
 



Total histology score

Crypt damage

Severity of colitis

Ulceratedsurface
  score score score 
WT plus DSS 17.9 ± 0.7b,d 6.7 ± 0.4b,d 7.4 ± 0.3b 20.3 ± 1.8b 
iNOS−/− plus DSS 12.0 ± 1.5a,d 4.4 ± 0.6a, d 4.7 ± 0.7a,d 7.4 ± 0.8a,c,d 
p47phox−/− plus DSS 16.3 ± 1.4d 6.9 ± 0.6d 6.1 ± 0.7d 15.9 ± 2.3b 
SODTg plus DSS 23.9 ± 1.3a&ca–c 10.4 ± 0.8a&ca–c 9.1 ± 0.5b,c 22.0 ± 2.0b 
WT (conv.) plus DSS 18.8 ± 1.6 7.1 ± 0.5 7.8 ± 0.5 22.8 ± 3.5 
iNOS−/− (conv.)
 
plus DSS
 
11.4 ± 2.0e
 
3.9 ± 1.7e
 
4.3 ± 0.9e
 
6.2 ± 2.7e
 
a

P < 0.05 vs. WT.

b

P < 0.05 vs. iNOS−/−.

c

P < 0.05 vs. p47phox−/−.

d

P < 0.05 vs. SODTg.

e

P < 0.05 vs. WT (conv.).

Blinded histologic assessment of colitis after oral treatment with DSS for 7 d in WT, iNOS−/−, p47phox−/−, and SODTg mice (n = 9/group). In addition DSS-treated WT versus iNOS−/− mice under conventional housing conditions (n = 5/group). Based on validated scoring system and morphometry described in Materials and Methods. Mean ± SEM.

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