Rockefeller University Press

Table III.

B Cell Overproduction and Increased in Lin⁻Sca-1⁺c-Kit⁺ Hematopoietic Progenitors in lnk^−/− Mice Is Partly Normalized by Reducing Expression of c-Kit

Genotype	Cell number	B220^loIgM⁻	B220^loIgM⁺		Lin⁻Sca-1⁺c-Kit⁺
	(10⁷ cells/femur)	(%)	(%)		(%)	(% in Lin⁻ cells)
lnk^+/+Kit^+/+	1.65 ± 0.16	19.5 ± 5.1	8.9 ± 3.6	(n = 12)	0.45 ± 0.07	16.2 ± 2.2	(n = 5)
lnk^+/+Kit^W/+	1.71 ± 0.19	18.2 ± 4.6	8.0 ± 3.1	(n = 10)	0.38 ± 0.06	14.9 ± 1.7	(n = 4)
lnk^−/−Kit^+/+	2.03 ± 0.37^{^a}	3.6 ± 4.8^{^a}	14.1 ± 2.1^{^a}	(n = 11)	0.70 ± 0.06^{^a}	26.1 ± 2.1^{^a}	(n = 5)
lnk^−/−Kit^W/+	1.91 ± 0.28	28.9 ± 3.9^{^b}	11.8 ± 1.7^{^b}	(n = 8)	0.56 ± 0.13	21.3 ± 1.4^{^b}	(n = 5)

Genotype	Cell number	B220^loIgM⁻	B220^loIgM⁺		Lin⁻Sca-1⁺c-Kit⁺
	(10⁷ cells/femur)	(%)	(%)		(%)	(% in Lin⁻ cells)
lnk^+/+Kit^+/+	1.65 ± 0.16	19.5 ± 5.1	8.9 ± 3.6	(n = 12)	0.45 ± 0.07	16.2 ± 2.2	(n = 5)
lnk^+/+Kit^W/+	1.71 ± 0.19	18.2 ± 4.6	8.0 ± 3.1	(n = 10)	0.38 ± 0.06	14.9 ± 1.7	(n = 4)
lnk^−/−Kit^+/+	2.03 ± 0.37^{^a}	3.6 ± 4.8^{^a}	14.1 ± 2.1^{^a}	(n = 11)	0.70 ± 0.06^{^a}	26.1 ± 2.1^{^a}	(n = 5)
lnk^−/−Kit^W/+	1.91 ± 0.28	28.9 ± 3.9^{^b}	11.8 ± 1.7^{^b}	(n = 8)	0.56 ± 0.13	21.3 ± 1.4^{^b}	(n = 5)

P < 0.05 compared to lnk^+/+Kit^+/+.

P < 0.05 compared to lnk^−/−Kit^+/+.

Bone marrow cells obtained from 8–10-wk-old mice were analyzed, and mean cell number (±SD), mean percentage (±SD) of the indicated cell fractions and the number of mice analyzed are shown.

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