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Table I.

Baseline Characteristics of Study Subjects and Their Estimated Values of CD4+ and CD8+ Lymphocyte Proliferation (p), Death (d), and Fractional Input from a Source (U)




Baseline values

CD4+

CD8+
SubjectsAge(sex)Plasma viral loadCD4+CD8+p(95% CI)d(95% CI)U(95% CI)p(95% CI)d(95% CI)U(95% CI)
  (copies/ml) μl−1 μl−1 day−1 day−1 day−1 day−1 day−1 day−1 
Controls:           
C1 43 (M) 880 562 0.005
 (0.005-0.006) 0.057
 (0.024-0.110) 0.044
 (0.016-0.094) 0.004
 (0.003-0.005) 0.076
 (0.044-0.139) 0.072
 (0.041-0.134) 
C2 22 (F) 992 576 0.004
 (0.003-0.011) 0.064
 (0.024-0.496) 0.060
 (0.020-0.485) 0.002
 (0.002-0.003) 0.018
 (0.013-0.090) 0.016
 (0.011-0.087) 
C3 22 (F) 1,366 651 0.003
 (0.001-0.131) 0.013
 (0.002-10.9) 0.010
 (0.000-10.7) 0.002
 (0.001-0.006) 0.008
 (0.002-1.36) 0.006
 (0.000-1.34) 
C4
 
22 (M)
 
-
 
1,066
 
621
 
0.004
 (0.003-0.005)
 
0.042
 (0.029-0.120)
 
0.020
 (0.013-0.065)
 
0.002
 (0.002-0.003)
 
0.070
 (0.016-0.196)
 
0.067
 (0.014-0.192)
 
Mean ± SE 30.0 1,076 603 0.004 ± 0.0005 0.044 ± 0.011 0.033 ± 0.011 0.003 ± 0.0004 0.043 ± 0.017 0.040 ± 0.017 
Infected:           
P1 38 (M) 500,000 322 806 0.033
 (0.028-0.041) 0.112
 (0.071-0.167) 0.077
 (0.045-0.123) 0.036
 (0.033-0.040) 0.065
 (0.038-0.090) 0.046
 (0.025-0.078) 
P2 24 (M) 226,087 255 494 0.034
 (0.027-0.042) 0.135
 (0.086-0.255) 0.100
 (0.056-0.214) 0.018
 (0.015-0.022) 0.092
 (0.064-0.272) 0.074
 (0.049-0.249) 
P3 26 (M) 7,629 323 617 0.010
 (0.009-0.010) 0.042
 (0.025-0.068) 0.050
 (0.034-0.081) 0.010
 (0.009-0.011) 0.029
 (0.018-0.072) 0.031
 (0.020-0.077) 
P4 46 (F) 61,946 48 323 0.039
 (0.036-0.047) 0.082
 (0.053-0.131) 0.042
 (0.016-0.086) 0.024
 (0.022-0.029) 0.032
 (0.024-0.059) 0.008
 (0.003-0.032) 
P5 38 (M) 88,997 804 1,148 0.019
 (0.015-0.160) 0.306
 (0.153-3.8) 0.285
 (0.137-3.61) 0.029
 (0.026-0.035) 0.062
 (0.034-0.157) 0.022
 (0.012-0.072) 
P6 21 (M) 13,367 626 1,312 0.016
 (0.014-0.019) 0.151
 (0.095-0.214) 0.240
 (0.115-0.641) 0.024
 (0.023-0.026) 0.049
 (0.038-0.067) 0.024
 (0.015-0.041) 
P7
 
36 (F)
 
22,410
 
337
 
1,011
 
0.022
 (0.021-0.023)
 
0.077
 (0.060-0.093)
 
0.065
 (0.045-0.079)
 
0.017
 (0.016-0.019)
 
0.022
 (0.015-0.060)
 
0.011
 (0.007-0.050)
 
Mean ± SE
 
32.6
 
131,491
 
388
 
816
 
0.025 ± 0.004a
 
0.129 ± 0.033a
 
0.123 ± 0.037a
 
0.023 ± 0.003a
 
0.050 ± 0.009
 
0.031 ± 0.009
 



Baseline values

CD4+

CD8+
SubjectsAge(sex)Plasma viral loadCD4+CD8+p(95% CI)d(95% CI)U(95% CI)p(95% CI)d(95% CI)U(95% CI)
  (copies/ml) μl−1 μl−1 day−1 day−1 day−1 day−1 day−1 day−1 
Controls:           
C1 43 (M) 880 562 0.005
 (0.005-0.006) 0.057
 (0.024-0.110) 0.044
 (0.016-0.094) 0.004
 (0.003-0.005) 0.076
 (0.044-0.139) 0.072
 (0.041-0.134) 
C2 22 (F) 992 576 0.004
 (0.003-0.011) 0.064
 (0.024-0.496) 0.060
 (0.020-0.485) 0.002
 (0.002-0.003) 0.018
 (0.013-0.090) 0.016
 (0.011-0.087) 
C3 22 (F) 1,366 651 0.003
 (0.001-0.131) 0.013
 (0.002-10.9) 0.010
 (0.000-10.7) 0.002
 (0.001-0.006) 0.008
 (0.002-1.36) 0.006
 (0.000-1.34) 
C4
 
22 (M)
 
-
 
1,066
 
621
 
0.004
 (0.003-0.005)
 
0.042
 (0.029-0.120)
 
0.020
 (0.013-0.065)
 
0.002
 (0.002-0.003)
 
0.070
 (0.016-0.196)
 
0.067
 (0.014-0.192)
 
Mean ± SE 30.0 1,076 603 0.004 ± 0.0005 0.044 ± 0.011 0.033 ± 0.011 0.003 ± 0.0004 0.043 ± 0.017 0.040 ± 0.017 
Infected:           
P1 38 (M) 500,000 322 806 0.033
 (0.028-0.041) 0.112
 (0.071-0.167) 0.077
 (0.045-0.123) 0.036
 (0.033-0.040) 0.065
 (0.038-0.090) 0.046
 (0.025-0.078) 
P2 24 (M) 226,087 255 494 0.034
 (0.027-0.042) 0.135
 (0.086-0.255) 0.100
 (0.056-0.214) 0.018
 (0.015-0.022) 0.092
 (0.064-0.272) 0.074
 (0.049-0.249) 
P3 26 (M) 7,629 323 617 0.010
 (0.009-0.010) 0.042
 (0.025-0.068) 0.050
 (0.034-0.081) 0.010
 (0.009-0.011) 0.029
 (0.018-0.072) 0.031
 (0.020-0.077) 
P4 46 (F) 61,946 48 323 0.039
 (0.036-0.047) 0.082
 (0.053-0.131) 0.042
 (0.016-0.086) 0.024
 (0.022-0.029) 0.032
 (0.024-0.059) 0.008
 (0.003-0.032) 
P5 38 (M) 88,997 804 1,148 0.019
 (0.015-0.160) 0.306
 (0.153-3.8) 0.285
 (0.137-3.61) 0.029
 (0.026-0.035) 0.062
 (0.034-0.157) 0.022
 (0.012-0.072) 
P6 21 (M) 13,367 626 1,312 0.016
 (0.014-0.019) 0.151
 (0.095-0.214) 0.240
 (0.115-0.641) 0.024
 (0.023-0.026) 0.049
 (0.038-0.067) 0.024
 (0.015-0.041) 
P7
 
36 (F)
 
22,410
 
337
 
1,011
 
0.022
 (0.021-0.023)
 
0.077
 (0.060-0.093)
 
0.065
 (0.045-0.079)
 
0.017
 (0.016-0.019)
 
0.022
 (0.015-0.060)
 
0.011
 (0.007-0.050)
 
Mean ± SE
 
32.6
 
131,491
 
388
 
816
 
0.025 ± 0.004a
 
0.129 ± 0.033a
 
0.123 ± 0.037a
 
0.023 ± 0.003a
 
0.050 ± 0.009
 
0.031 ± 0.009
 
a

Mean values in infected patients that are significantly different (P value <0.05 by Wilcoxon rank sum U-test) from those in normal persons.

CI, confidence interval.

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