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Table I.

Hematologic Parameters in wt and ΔdblGATA Mice


Sex

dblGATA Genotype

WBC

RBC

HGB

HCT

MCV

PLT

MPV

Manual EO
  103/μl 106/μl g/dL fL 103/μl fL 
het 6.60 8.75 14.0 44.5 50.9 1885 14.6 1–2 
hom 4.10 8.25 14.5 44.0 53.6 1090 21.7 0 
hom 8.20 8.25 14.0 44.5 54.1 1635 16.5 0 
wt 5.60 8.95 14.5 44.0 49.2 1460 21.7 1–2 
wt 12.65 9.50 14.5 45.0 47.6 2205 17.1 1–2 
hem 7.50 7.30 11.0 36.0 49.0 1950 15.9 0 
M
 
hem
 
8.15
 
8.15
 
13.5
 
43.5
 
53.2
 
1095
 
18.3
 
0
 

Sex

dblGATA Genotype

WBC

RBC

HGB

HCT

MCV

PLT

MPV

Manual EO
  103/μl 106/μl g/dL fL 103/μl fL 
het 6.60 8.75 14.0 44.5 50.9 1885 14.6 1–2 
hom 4.10 8.25 14.5 44.0 53.6 1090 21.7 0 
hom 8.20 8.25 14.0 44.5 54.1 1635 16.5 0 
wt 5.60 8.95 14.5 44.0 49.2 1460 21.7 1–2 
wt 12.65 9.50 14.5 45.0 47.6 2205 17.1 1–2 
hem 7.50 7.30 11.0 36.0 49.0 1950 15.9 0 
M
 
hem
 
8.15
 
8.15
 
13.5
 
43.5
 
53.2
 
1095
 
18.3
 
0
 

Automated measurement of blood from adult wt and ΔdblGATA mutant mouse littermates from a cross between heterozygous mutant female and a hemizygous mutant male. The dblGATA genotype is designated as follows: het, heterozygous (ΔdblGATA/+) mutant female; hom, homozygous (ΔdblGATA/ΔdblGATA) mutant female; wt, wild-type (+/Y) male; and hem, hemizygous (ΔdblGATA/Y) mutant male. Eosinophils are not observed in homozygous ΔdblGATA mutant females or hemizygous ΔdblGATA mutant males. HCT, hematocrit; HGB, hemoglobin concentration; MCV, mean corpuscular volume; MPV, mean platelet volume; manual EO, manual differential count of eosinophils by a blinded observer; PLT; platelet count; RBC, erythrocyte count; WBC, leukocyte count.

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