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Table II.

Prospective Study of A2.1 Epitope Response



Lytic
 epitopes

Latent
 epitope
Donor
 (time post-IM)
YVL
GLC
TLD
CLG
13.1 20.3 0.8 1.6 
13.5 (14 yr) 1.1 0.8 
79.1 29.0 0.7 6.1 0.1 
79.2 (30 mo) 1.9 0.4 0.4 0.1 
79.3 (60 mo) 2.4 1.4 1.0 0.2 
81.1 33.6 11.8 1.0 
81.2 (30 mo) 0.9 0.4 0.05 
81.3 (36 mo) 1.2 0.3 0.3 
81.4 (44 mo) 1.2 0.3 0.1 
81.5 (54 mo) 1.1 0.4 0.2 
113.1 2.7 1.9 0.4 
113.2 (14 mo) 0.2 0.6 0.05 0.05 
113.3 (17 mo) 0.2 0.5 0.1 
113.4 (25 mo) 0.2 0.3 0.1 
119.1 7.3 3.6 0.6 
119.2 (4 mo) 1.3 1.4 0.05 
119.3 (10 mo) 0.5 0.8 
123.1 9.8 6.5 0.5 
123.2 (2 mo) 4.8 2.4 0.1 
123.3 (11 mo) 1.8 0.9 0.1 
130.1 4.1 0.7 0.3 
130.2 (5 mo) 0.2 0.2 
130.3 (12 mo) 0.1 0.2 
130.4 (20 mo) 0.1 0.1 
140.1 4.1 7.3 1.1 
140.2 (3 mo) 1.9 4.0 0.8 0.3 
140.3 (8 mo) 1.1 2.5 0.2 0.3 
140.4 (10 mo) 1.1 2.3 0.0 0.1 
140.5 (14 mo) 1.0 1.5 0.0 0.3 
146.1 3.1 1.0 3.3 
146.2 (4 mo) 0.7 0.3 0.7 0.3 
146.3 (12 mo)
 
0.7
 
0.4
 
0
 
0.4
 


Lytic
 epitopes

Latent
 epitope
Donor
 (time post-IM)
YVL
GLC
TLD
CLG
13.1 20.3 0.8 1.6 
13.5 (14 yr) 1.1 0.8 
79.1 29.0 0.7 6.1 0.1 
79.2 (30 mo) 1.9 0.4 0.4 0.1 
79.3 (60 mo) 2.4 1.4 1.0 0.2 
81.1 33.6 11.8 1.0 
81.2 (30 mo) 0.9 0.4 0.05 
81.3 (36 mo) 1.2 0.3 0.3 
81.4 (44 mo) 1.2 0.3 0.1 
81.5 (54 mo) 1.1 0.4 0.2 
113.1 2.7 1.9 0.4 
113.2 (14 mo) 0.2 0.6 0.05 0.05 
113.3 (17 mo) 0.2 0.5 0.1 
113.4 (25 mo) 0.2 0.3 0.1 
119.1 7.3 3.6 0.6 
119.2 (4 mo) 1.3 1.4 0.05 
119.3 (10 mo) 0.5 0.8 
123.1 9.8 6.5 0.5 
123.2 (2 mo) 4.8 2.4 0.1 
123.3 (11 mo) 1.8 0.9 0.1 
130.1 4.1 0.7 0.3 
130.2 (5 mo) 0.2 0.2 
130.3 (12 mo) 0.1 0.2 
130.4 (20 mo) 0.1 0.1 
140.1 4.1 7.3 1.1 
140.2 (3 mo) 1.9 4.0 0.8 0.3 
140.3 (8 mo) 1.1 2.5 0.2 0.3 
140.4 (10 mo) 1.1 2.3 0.0 0.1 
140.5 (14 mo) 1.0 1.5 0.0 0.3 
146.1 3.1 1.0 3.3 
146.2 (4 mo) 0.7 0.3 0.7 0.3 
146.3 (12 mo)
 
0.7
 
0.4
 
0
 
0.4
 

The lytic epitope responses decrease significantly over time. (YVL: P = 0.0008, GLC: P = 0.02, TLD: P = 0.002). These figures are the result of modeling each of the lytic epitopes as log(response) using SAS PROC MIXED with a random effect for intercept and with fixed and random effects for time. Combining these into a single model suggests different rates of fall between epitopes (P = 0.003 for fixed epitope time interaction effect). The latent epitope response shows no such effect.

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