Cell Death Induced by Aβ Peptides
. | BENTR-free . | . | BEp75 . | . | BEp75TrkA . | . | |||
|---|---|---|---|---|---|---|---|---|---|
. | 24 h . | 48 h . | 24 h . | 48 h . | 24 h . | 24 h . | |||
| Controls | 5.9 ± 2.6a(18) | 7.8 ± 2.6 (18) | 8.2 ± 2.2 (62) | 9.2 ± 2.4 (20) | 5.3 ± 2.5 (3) | 10.3 ± 2.1 (3) | |||
| Aβ(25–35) | 5.2 ± 2.6 (12) | 6.2 ± 2.8 (12) | 29.7 ± 4.5b(65) | 34.0 ± 4.8b (14) | 7.1 ± 3.1 (5) | 28.5 ± 6.3b (5) | |||
| Aβ(1–40) | 5.6 ± 2.3 (5) | 5.5 ± 2.8 (4) | 27.6 ± 2.3b (5) | 33.2 ± 6.2b (4) | |||||
| Aβ(1–42) | 5.6 ± 1.6 (5) | 7.3 ± 1.8 (4) | 30.0 ± 2.5b (3) | 30.9 ± 2.2b (4) | |||||
. | BENTR-free . | . | BEp75 . | . | BEp75TrkA . | . | |||
|---|---|---|---|---|---|---|---|---|---|
. | 24 h . | 48 h . | 24 h . | 48 h . | 24 h . | 24 h . | |||
| Controls | 5.9 ± 2.6a(18) | 7.8 ± 2.6 (18) | 8.2 ± 2.2 (62) | 9.2 ± 2.4 (20) | 5.3 ± 2.5 (3) | 10.3 ± 2.1 (3) | |||
| Aβ(25–35) | 5.2 ± 2.6 (12) | 6.2 ± 2.8 (12) | 29.7 ± 4.5b(65) | 34.0 ± 4.8b (14) | 7.1 ± 3.1 (5) | 28.5 ± 6.3b (5) | |||
| Aβ(1–40) | 5.6 ± 2.3 (5) | 5.5 ± 2.8 (4) | 27.6 ± 2.3b (5) | 33.2 ± 6.2b (4) | |||||
| Aβ(1–42) | 5.6 ± 1.6 (5) | 7.3 ± 1.8 (4) | 30.0 ± 2.5b (3) | 30.9 ± 2.2b (4) | |||||
The values express percentages of cell death and are means ±SD of the experiments indicated within brackets.
P < 0.001 with respect to the controls of the corresponding time point.
Cells were treated with Aβ(25–35) (20 μM), Aβ(1–40) (5.0 μM), or Aβ(1–42) (5.0 μM) and cell death was assessed by epifluorescence microscopy after 24 and 48 h.