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Table III.

MHV-68 Lytic and Latency-associated Transcripts Analyzed


Gene

Function and/or homology

References
M1 Serpin homologue (poxvirus), M3 homologue, suppresses reactivation from latency 59  
M2 Differentially required for acute replication and establishment of latency 60, 61  
M3 Chemokine scavenger 40, 46, 47  
M9 Unknown 15  
M11 Bcl-2 homologue (EBV, KSHV), apoptosis inhibitor 48, 62  
ORF 72 Cyclin-D homologue (KSHV), transforming potential, controls reactivation from latency 63–65  
ORF 73 Putative genome maintenance function based on homology to KSHV-LANA 15  
ORF 74 G protein–coupled receptor; homology to IL-8R (KSHV), transforming potential 66  
ORF 50 Lytic cycle activator, homologous to EBV-Rta transactivator 42–44  
K3
 
Homologous to KSHV K3 and K5, inhibits class I antigen presentation
 
67, 68 
 

Gene

Function and/or homology

References
M1 Serpin homologue (poxvirus), M3 homologue, suppresses reactivation from latency 59  
M2 Differentially required for acute replication and establishment of latency 60, 61  
M3 Chemokine scavenger 40, 46, 47  
M9 Unknown 15  
M11 Bcl-2 homologue (EBV, KSHV), apoptosis inhibitor 48, 62  
ORF 72 Cyclin-D homologue (KSHV), transforming potential, controls reactivation from latency 63–65  
ORF 73 Putative genome maintenance function based on homology to KSHV-LANA 15  
ORF 74 G protein–coupled receptor; homology to IL-8R (KSHV), transforming potential 66  
ORF 50 Lytic cycle activator, homologous to EBV-Rta transactivator 42–44  
K3
 
Homologous to KSHV K3 and K5, inhibits class I antigen presentation
 
67, 68 
 
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