Skip to Main Content
Table I.

Comparison of PAMPs and Virulence Factors


PAMPs

Virulence Factors
Invariant products of conserved
   metabolic pathways Differ between
 different pathogens 
Evolved to perform essential
   physiological functions of
   microorganisms Evolved as a result
 of adaptation to the host 
Not unique to pathogens.
   Produced by all
   microorganisms of a
   given class Unique to pathogens 
Targets of innate
   immune recognition
 
Not recognized directly by
 PRRs. Some virulence factors
 may interact with PRRs to
 manipulate the host innate
 immune response
 

PAMPs

Virulence Factors
Invariant products of conserved
   metabolic pathways Differ between
 different pathogens 
Evolved to perform essential
   physiological functions of
   microorganisms Evolved as a result
 of adaptation to the host 
Not unique to pathogens.
   Produced by all
   microorganisms of a
   given class Unique to pathogens 
Targets of innate
   immune recognition
 
Not recognized directly by
 PRRs. Some virulence factors
 may interact with PRRs to
 manipulate the host innate
 immune response
 
Close Modal

or Create an Account

Close Modal
Close Modal