Hemodynamic and Microvascular Parameters in Trauma- and TNF-α–induced Inflammation
Mouse genotype . | Mice . | Venules . | Diameter . | Centerline velocity . | Wall shear rate . | Systemic leukocyte counts . |
|---|---|---|---|---|---|---|
| n | n | μm | μm/s | s−1 | cells/μl | |
| Trauma | ||||||
| PSGL-1−/− | 7 | 80 | 31 ± 1 | 2,900 ± 300 | 900 ± 300 | 8,600 ± 900* |
| Wild-type | 9 | 70 | 32 ± 1 | 2,900 ± 300 | 1,000 ± 100 | 5,800 ± 500* |
| Chimera | 3 | 37 | 32 ± 3 | 3,200 ± 700 | 1,000 ± 200 | 7,200 ± 300 |
| TNF-α | ||||||
| PSGL-1−/− | 4 | 37 | 29 ± 2 | 1,800 ± 200 | 690 ± 110 | 3,000 ± 300 |
| Wild-type | 4 | 54 | 29 ± 1 | 1,800 ± 100 | 630 ± 50 | 2,200 ± 200 |
| Chimera | 2 | 16 | 31 ± 1 | 1,900 ± 200 | 700 ± 80 | 5,300 ± 600 |
Mouse genotype . | Mice . | Venules . | Diameter . | Centerline velocity . | Wall shear rate . | Systemic leukocyte counts . |
|---|---|---|---|---|---|---|
| n | n | μm | μm/s | s−1 | cells/μl | |
| Trauma | ||||||
| PSGL-1−/− | 7 | 80 | 31 ± 1 | 2,900 ± 300 | 900 ± 300 | 8,600 ± 900* |
| Wild-type | 9 | 70 | 32 ± 1 | 2,900 ± 300 | 1,000 ± 100 | 5,800 ± 500* |
| Chimera | 3 | 37 | 32 ± 3 | 3,200 ± 700 | 1,000 ± 200 | 7,200 ± 300 |
| TNF-α | ||||||
| PSGL-1−/− | 4 | 37 | 29 ± 2 | 1,800 ± 200 | 690 ± 110 | 3,000 ± 300 |
| Wild-type | 4 | 54 | 29 ± 1 | 1,800 ± 100 | 630 ± 50 | 2,200 ± 200 |
| Chimera | 2 | 16 | 31 ± 1 | 1,900 ± 200 | 700 ± 80 | 5,300 ± 600 |
Diameter, centerline velocity, and wall shear rate are presented as mean ± SEM of all investigated venules. Significant difference (P < 0.05) in systemic leukocyte counts is indicated by *.