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Table I.

Hemodynamic and Microvascular Parameters in Trauma- and TNF-α–induced Inflammation


Mouse genotype

Mice

Venules

Diameter

Centerline velocity

Wall shear
 rate

Systemic
 leukocyte counts
 μm μm/s s−1 cells/μl 
Trauma       
PSGL-1−/− 80 31 ± 1 2,900 ± 300 900 ± 300 8,600 ± 900* 
Wild-type 70 32 ± 1 2,900 ± 300 1,000 ± 100 5,800 ± 500* 
Chimera 37 32 ± 3 3,200 ± 700 1,000 ± 200 7,200 ± 300 
TNF-α       
PSGL-1−/− 37 29 ± 2 1,800 ± 200 690 ± 110 3,000 ± 300 
Wild-type 54 29 ± 1 1,800 ± 100 630 ± 50 2,200 ± 200 
Chimera
 
2
 
16
 
31 ± 1
 
1,900 ± 200
 
700 ± 80
 
5,300 ± 600
 

Mouse genotype

Mice

Venules

Diameter

Centerline velocity

Wall shear
 rate

Systemic
 leukocyte counts
 μm μm/s s−1 cells/μl 
Trauma       
PSGL-1−/− 80 31 ± 1 2,900 ± 300 900 ± 300 8,600 ± 900* 
Wild-type 70 32 ± 1 2,900 ± 300 1,000 ± 100 5,800 ± 500* 
Chimera 37 32 ± 3 3,200 ± 700 1,000 ± 200 7,200 ± 300 
TNF-α       
PSGL-1−/− 37 29 ± 2 1,800 ± 200 690 ± 110 3,000 ± 300 
Wild-type 54 29 ± 1 1,800 ± 100 630 ± 50 2,200 ± 200 
Chimera
 
2
 
16
 
31 ± 1
 
1,900 ± 200
 
700 ± 80
 
5,300 ± 600
 

Diameter, centerline velocity, and wall shear rate are presented as mean ± SEM of all investigated venules. Significant difference (P < 0.05) in systemic leukocyte counts is indicated by *.

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