Sequence Alignment of L5
. | . | β4___________β5 . | . | . | β4___________β5 . |
|---|---|---|---|---|---|
| AChBP | : | LAAYN-AISKPEV | AChBP | : | LAAYN-AISKPEV |
| M.alpha1 | : | VVLYNNADGDFAI | X.lealpha1 | : | LVLYNNADGDFAI |
| M.alpha2 | : | IVLYNNADGEFAV | G.gaalpha1 | : | LVLYNNADGDFAI |
| M.alpha3 | : | IVLYNNADGDFQV | B.toalpha1 | : | IVLYNNAVGDFQV |
| M.alpha4 | : | IVLYNNADGNFAV | D.mealpha1 | : | IVLYNNADGNYEV |
| M.alpha5 | : | IVLFDNADGRFEG | C.elalpha1 | : | VVLYNNADGNYQV |
| M.alpha6 | : | IVLYNNAVGDFQV | L.mialpha1 | : | IVLTNNSEGNFEV |
| M.alpha7 | : | ILLYNSADERFDA | H.5HT3AS | : | ILINEFVDVGKSP |
| M.alpha9 | : | ILLAMTVFQLMVA | M.5HT3AS | : | ILINEFVDVGKSP |
| M.beta1 | : | VLLNNNDGNFDVA | H.5HT3B | : | IIINEFVDIERYP |
| M.beta2 | : | IVLYNNADGEFAV | M.5HT3B | : | IIINEFVDVERSP |
| M.beta3 | : | IVLFENADGRFEG | H.GABAA1 | : | TFFHNGKKSVAHN |
| M.beta4 | : | IVLYNNADGTYEV | M.GABAA1 | : | TFFHNGKKSVAHN |
| M.deltal | : | IVLENNNDGSFQI | H.GABAB1 | : | TYFLNDKKSFVHG |
| M.epsilon1 | : | IVLENNIDGQFGV | M.GABAB1 | : | TYFLNDKKSFVHG |
| M.gamma1 | : | IVLENNVDGVFEV | H.GABAD1 | : | TFIVNAKSAWFHD |
| M.mualpha1 | : | VVLYNNADGDFAI | M.GABAD1 | : | TFIVNAKSAWFHD |
| R.noalpha1 | : | VVLYNNADGDFAI | H.GABAGS | : | TFFRNSKKADAHW |
| H.saalpha1 | : | LVLYNNADGDFAI | M.GABAGS | : | TFFRNSKKADAHW |
| T.caalpha1 | : | LVLYNNADGDFAI | H.GlyA1 | : | LFFANEKGAHFHE |
| A.caalpha1 | : | IVLYNNADGNYEV | M.GlyA1 | : | LFFANEKGAHFHE |
. | . | β4___________β5 . | . | . | β4___________β5 . |
|---|---|---|---|---|---|
| AChBP | : | LAAYN-AISKPEV | AChBP | : | LAAYN-AISKPEV |
| M.alpha1 | : | VVLYNNADGDFAI | X.lealpha1 | : | LVLYNNADGDFAI |
| M.alpha2 | : | IVLYNNADGEFAV | G.gaalpha1 | : | LVLYNNADGDFAI |
| M.alpha3 | : | IVLYNNADGDFQV | B.toalpha1 | : | IVLYNNAVGDFQV |
| M.alpha4 | : | IVLYNNADGNFAV | D.mealpha1 | : | IVLYNNADGNYEV |
| M.alpha5 | : | IVLFDNADGRFEG | C.elalpha1 | : | VVLYNNADGNYQV |
| M.alpha6 | : | IVLYNNAVGDFQV | L.mialpha1 | : | IVLTNNSEGNFEV |
| M.alpha7 | : | ILLYNSADERFDA | H.5HT3AS | : | ILINEFVDVGKSP |
| M.alpha9 | : | ILLAMTVFQLMVA | M.5HT3AS | : | ILINEFVDVGKSP |
| M.beta1 | : | VLLNNNDGNFDVA | H.5HT3B | : | IIINEFVDIERYP |
| M.beta2 | : | IVLYNNADGEFAV | M.5HT3B | : | IIINEFVDVERSP |
| M.beta3 | : | IVLFENADGRFEG | H.GABAA1 | : | TFFHNGKKSVAHN |
| M.beta4 | : | IVLYNNADGTYEV | M.GABAA1 | : | TFFHNGKKSVAHN |
| M.deltal | : | IVLENNNDGSFQI | H.GABAB1 | : | TYFLNDKKSFVHG |
| M.epsilon1 | : | IVLENNIDGQFGV | M.GABAB1 | : | TYFLNDKKSFVHG |
| M.gamma1 | : | IVLENNVDGVFEV | H.GABAD1 | : | TFIVNAKSAWFHD |
| M.mualpha1 | : | VVLYNNADGDFAI | M.GABAD1 | : | TFIVNAKSAWFHD |
| R.noalpha1 | : | VVLYNNADGDFAI | H.GABAGS | : | TFFRNSKKADAHW |
| H.saalpha1 | : | LVLYNNADGDFAI | M.GABAGS | : | TFFRNSKKADAHW |
| T.caalpha1 | : | LVLYNNADGDFAI | H.GlyA1 | : | LFFANEKGAHFHE |
| A.caalpha1 | : | IVLYNNADGNYEV | M.GlyA1 | : | LFFANEKGAHFHE |
Sequence-alignment of L5 in AChBP and subunits from pentameric, “cys-loop” receptor channels. The line marks L5 in AChBP. In AChRs, the tyrosine (in mouse α1, Y93) forms a part of the ACh binding pocket. The apex of L5 is at residue I92 in AChBP and is in bold. See Fig. 1 for structures.