TABLE V

Desensitization Kinetics of Wild-type and αD97 Mutant AChR


α97

k01

k10

k12

k21

k23

k32

k34

k43
wt 33 ± 12 326 ± 133 293 ± 80 48 ± 6 39 ± 1 6.8 ± 0.6 3.3 ± 0.3 0.33 ± 0.01 
37 ± 1 286 ± 26 146 ± 18 24 ± 10 17 ± 7 1.27 ± 0.4 0.92 ± 0.4 0.25 ± 0.12 
H
 
41 ± 7
 
311 ± 86
 
257 ± 92
 
80 ± 42
 
77 ± 39
 
5.7 ± 1.8
 
3.29 ± 1
 
0.53 ± 0.15
 

α97

k01

k10

k12

k21

k23

k32

k34

k43
wt 33 ± 12 326 ± 133 293 ± 80 48 ± 6 39 ± 1 6.8 ± 0.6 3.3 ± 0.3 0.33 ± 0.01 
37 ± 1 286 ± 26 146 ± 18 24 ± 10 17 ± 7 1.27 ± 0.4 0.92 ± 0.4 0.25 ± 0.12 
H
 
41 ± 7
 
311 ± 86
 
257 ± 92
 
80 ± 42
 
77 ± 39
 
5.7 ± 1.8
 
3.29 ± 1
 
0.53 ± 0.15
 

Closed and open intervals in the record were fitted using the linear model shown in Fig. 6. Rate constants are s−1. The wt values are from Elenes and Auerbach (2002). The values are means ± SEM for three patches activated by 100 μM ACh.

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