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Table II.

Proliferation and Disappearance Rates for T_CM, T_EM, Naive, and RA⁺7⁻ CD4⁺ T Cells

	Proliferation							Disappearance
	CCR7⁺			CCR7⁻			CCR7⁺		CCR7⁻
	CD45R0⁺
Subject	p	t₂	p	t₂	d*	t_1/2	d*	t_1/2
%/day	%/day	days	%/day	days	%/day	days	%/day	days
C09	1.15	60	5.01	14	11.53	6.0	16.16	4.3
C11	0.74	94	7.59	9	0.00	>^{^c}	20.28	3.4
C12	1.05	66	2.27	31	0.00	>	8.00	8.7
C13	1.03	67	7.41	9	2.32	29.9	11.61	6.0
C14	1.00	69	2.83	24	3.20	21.7	6.56	10.6
C15	3.77	18	3.31	21	7.74	9.0	5.26	13.2
Mean	1.46	48	4.74^{^a}	15	4.13	17	11.31^{^a}	6
± SD	±1.14		±2.33		±4.61		±5.90
	CD45RA⁺
C11	0.16	433	ND^{^b}	ND	0.00	>	ND	ND
C12	0.37	187	0.84	83	0.00	>	0.00	>
C13	0.11	630	2.51	28	0.00	>	10.35	6.7
C14	0.12	578	4.44	16	0.00	>	4.02	17.2
C15	0.20	347	5.56	12	0.00	>	8.95	7.7
Mean	0.19	361	3.34^{^a}	21	0.00	>	5.83^{^a}	12
±SD	±0.11		±2.09		±0.00		±4.74

	Proliferation							Disappearance
	CCR7⁺			CCR7⁻			CCR7⁺		CCR7⁻
	CD45R0⁺
Subject	p	t₂	p	t₂	d*	t_1/2	d*	t_1/2
%/day	%/day	days	%/day	days	%/day	days	%/day	days
C09	1.15	60	5.01	14	11.53	6.0	16.16	4.3
C11	0.74	94	7.59	9	0.00	>^{^c}	20.28	3.4
C12	1.05	66	2.27	31	0.00	>	8.00	8.7
C13	1.03	67	7.41	9	2.32	29.9	11.61	6.0
C14	1.00	69	2.83	24	3.20	21.7	6.56	10.6
C15	3.77	18	3.31	21	7.74	9.0	5.26	13.2
Mean	1.46	48	4.74^{^a}	15	4.13	17	11.31^{^a}	6
± SD	±1.14		±2.33		±4.61		±5.90
	CD45RA⁺
C11	0.16	433	ND^{^b}	ND	0.00	>	ND	ND
C12	0.37	187	0.84	83	0.00	>	0.00	>
C13	0.11	630	2.51	28	0.00	>	10.35	6.7
C14	0.12	578	4.44	16	0.00	>	4.02	17.2
C15	0.20	347	5.56	12	0.00	>	8.95	7.7
Mean	0.19	361	3.34^{^a}	21	0.00	>	5.83^{^a}	12
±SD	±0.11		±2.09		±0.00		±4.74

P < 0.05 for CCR7⁺ versus CCR7⁻ by paired Student's t test.

ND indicates not determined because of inadequate data for model estimate.

> indicates t₂ or t_1/2 exceeds maximal value detectable (p or d* close to zero).

Values for proliferation (p) and disappearance (d*) rates were derived from the best fit curves applied to the data (see Materials and Methods). t₂ and t_1/2 represent doubling time or half-life equivalents of p or d*, respectively; mean values for t₂ and t_1/2 are calculated from the mean values for p and d*, respectively.

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