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Table I.

Breeding Results for insHEL Aire+/0 × TCR Aire+/0 Intercross (Gender Not Constant)


No. mice borna

177



No. mice weaneda 163 (8% fatality rate)    
No. dead pups unrecovereda    
Genotype of recovered dead pupsa 4× Aire0/0 double transgenic    
 3× Aire+/0 double transgenic    
Total no. dead pups recoveredb 35    
  Aire+/+ Aire+/0 Aire0/0 
Genotype of recovered pups Nontransgenic 
 insHEL 
 TCR 
 Double transgenic 21 
  Aire+/+ Aire+/0 Aire0/0 
Total no. weaned mice genotyped as double transgenicb 36 11 18 
 Observed 31% 50% 19% 

 
Expected
 
25%
 
50%
 
25%
 

No. mice borna

177



No. mice weaneda 163 (8% fatality rate)    
No. dead pups unrecovereda    
Genotype of recovered dead pupsa 4× Aire0/0 double transgenic    
 3× Aire+/0 double transgenic    
Total no. dead pups recoveredb 35    
  Aire+/+ Aire+/0 Aire0/0 
Genotype of recovered pups Nontransgenic 
 insHEL 
 TCR 
 Double transgenic 21 
  Aire+/+ Aire+/0 Aire0/0 
Total no. weaned mice genotyped as double transgenicb 36 11 18 
 Observed 31% 50% 19% 

 
Expected
 
25%
 
50%
 
25%
 
a

From subcohort of 11 breeder pairs where pups were counted at birth.

b

From a larger cohort where the number of pups born was not recorded.

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