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Table I.

Arguments in favor of a multipronged attack




Reference
1. Prevents escape mutants in immunodominant epitopes of SIV and HIV
 (and other viruses) 25–28  
2. Creates choices for the host to select the highest avidity TCRs 20  
3. Avoids holes in the repertoire 20  
4. Provides backup in case of clonal exhaustion or clonal anergy
 
29 
 



Reference
1. Prevents escape mutants in immunodominant epitopes of SIV and HIV
 (and other viruses) 25–28  
2. Creates choices for the host to select the highest avidity TCRs 20  
3. Avoids holes in the repertoire 20  
4. Provides backup in case of clonal exhaustion or clonal anergy
 
29 
 
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