Rockefeller University Press

Table I.

Characterization of MGCs in LCH lesions for osteoclast markers, osteoclast-secreted enzymes, and osteoclast-inducing environment

	MGCs in lesion
		Phenotypic markers of osteoclasts					Osteoclast-secreting enzymes			Osteoclast-inducing cytokines and receptor
Lesional site	CD1a	CD68	TRAP	VNR	CatK	MMP-9	M-CSF	RANKL	RANK
Bone
b1	–	++	++	++	++	++	#	#	#
b2	–	++	–	++	++	++	–	#	#
b3	–	–	–	–	–	–	#	#	#
b4	–	+	–	+	+	+	#	#	#
b5	–	++	++	++	+	++	–	#	#
b6	–	+++	+++	+++	+	++	#	#	#
b7	–	++	++	++	++	++	#	–	#
b8	–	–	–	–	–	–	#	#	#
b9	–	++	–	+	+	++	#	–	#
b10	–	++	++	+	+	++	#	–	#
b11	–	+	+	+	+	+	#	#	#
b12	–	+++	+++	+++	+++	+++	#	–	#
b13	–	++	–	+	+	++	–	#	#
b14	–	+++	+++	++	++	++	#	#	#
b15	–	+	+	+	+	+++	–	#	#
Skin
s1	++	++	++	++	++	+	#	#	#
s2	–	–	–	–	–	–	#	–	#
s3	–	–	–	–	–	–	ND	–	#
s4	–	–	–	–	–	–	ND	ND	–
s5	–	+	+	–	–	–	ND	ND	ND
s6	–	+	–	–	–	–	–	#	#
s7	–	–	–	–	–	–	–	–	–
Lymph node
l1	++	++	++	++	++	++	#	#	ND
l2	ND	+	+	+	+	+	#	#	#
l3	–	+++	–	+++	+++	+++	#	#	#
l4	+	+	+	+	+	+	–	#	#

	MGCs in lesion
		Phenotypic markers of osteoclasts					Osteoclast-secreting enzymes			Osteoclast-inducing cytokines and receptor
Lesional site	CD1a	CD68	TRAP	VNR	CatK	MMP-9	M-CSF	RANKL	RANK
Bone
b1	–	++	++	++	++	++	#	#	#
b2	–	++	–	++	++	++	–	#	#
b3	–	–	–	–	–	–	#	#	#
b4	–	+	–	+	+	+	#	#	#
b5	–	++	++	++	+	++	–	#	#
b6	–	+++	+++	+++	+	++	#	#	#
b7	–	++	++	++	++	++	#	–	#
b8	–	–	–	–	–	–	#	#	#
b9	–	++	–	+	+	++	#	–	#
b10	–	++	++	+	+	++	#	–	#
b11	–	+	+	+	+	+	#	#	#
b12	–	+++	+++	+++	+++	+++	#	–	#
b13	–	++	–	+	+	++	–	#	#
b14	–	+++	+++	++	++	++	#	#	#
b15	–	+	+	+	+	+++	–	#	#
Skin
s1	++	++	++	++	++	+	#	#	#
s2	–	–	–	–	–	–	#	–	#
s3	–	–	–	–	–	–	ND	–	#
s4	–	–	–	–	–	–	ND	ND	–
s5	–	+	+	–	–	–	ND	ND	ND
s6	–	+	–	–	–	–	–	#	#
s7	–	–	–	–	–	–	–	–	–
Lymph node
l1	++	++	++	++	++	++	#	#	ND
l2	ND	+	+	+	+	+	#	#	#
l3	–	+++	–	+++	+++	+++	#	#	#
l4	+	+	+	+	+	+	–	#	#

–, absence of expression; #, expression; +, 0–30% expression by the MGCs; ++, 30–70% expression by the MGCs; +++, 70–100% expression by the MGCs; ND, not determined due to lack of tissue.

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