Rockefeller University Press

Table I.

Patient characteristics

Patient	SLE100			SLE101			SLE122			SLE14	SLE21	SLE33
Gender	Female			Male			Female			Female	Female	Female
Age at  diagnosis	15 yr			15 yr			9 yr			11 yr	17 yr	7 yr
Date  of diagnosis	10/2002			10/2002			2/2003			11/1998	10/1999	7/2001
Sample	SLE100	SLE100CR	SLE101	SLE101CR	SLE122	SLE122CR	SLE14CR	SLE21CR	SLE33CR
Sample date	10/10/2002	2/12/2004	10/24/2002	3/3/2004	2/22/2003	9/14/2004	6/1/2005	7/21/2005	8/8/2005
Clinical  course	Arthritis,  nephritis IIB	Clinical  remission	Myocarditis,  nephritis III	Clinical  remission	Chorea,  nephritis  IIB	Clinical  remission	Clinical  remission	Clinical  remission	Clinical  remission
Therapy	None	Initially IV steroids  (stopped ∼3 mo),  continues on low  dose oral steroids,  PL, aspirin	None	Initially IV  steroids, CPH  (stopped ∼10  mo), continues  on IV steroids,  MMF, PL	None	Initially IV  steroids (stopped  ∼10 mo),  continues on  low dose oral  steroids	Initially IV CPH  and steroids  (stopped ∼4  yr), continues  on PL	Initially IV  steroids  (stopped ∼5  yr), continues  on PL	Initially IV  steroids  (stopped ∼3  yr), continues  on PL
Hematology	L, A, T	Normal	A	Normal	L, A	Normal	Normal	Normal	Normal
CD19⁺ cells  ×10³/ml		284		245		168	378	145	210
Renal	Abnormal	Normal	Abnormal	Normal	Borderline	Normal	Normal	Normal	Normal
ANA	+	+	+	+	+	+	NA	NA	NA
Serology	D, P, Sm,  RNP	Normal	P	Normal	D	Borderline D	D	Normal	Borderline D
ESR, mm/hr	11	25	>120	11	NA	41	50	10	12
Complement	Low	Normal	Low	Normal	Low	Normal	Normal	Normal	Normal

Patient	SLE100			SLE101			SLE122			SLE14	SLE21	SLE33
Gender	Female			Male			Female			Female	Female	Female
Age at  diagnosis	15 yr			15 yr			9 yr			11 yr	17 yr	7 yr
Date  of diagnosis	10/2002			10/2002			2/2003			11/1998	10/1999	7/2001
Sample	SLE100	SLE100CR	SLE101	SLE101CR	SLE122	SLE122CR	SLE14CR	SLE21CR	SLE33CR
Sample date	10/10/2002	2/12/2004	10/24/2002	3/3/2004	2/22/2003	9/14/2004	6/1/2005	7/21/2005	8/8/2005
Clinical  course	Arthritis,  nephritis IIB	Clinical  remission	Myocarditis,  nephritis III	Clinical  remission	Chorea,  nephritis  IIB	Clinical  remission	Clinical  remission	Clinical  remission	Clinical  remission
Therapy	None	Initially IV steroids  (stopped ∼3 mo),  continues on low  dose oral steroids,  PL, aspirin	None	Initially IV  steroids, CPH  (stopped ∼10  mo), continues  on IV steroids,  MMF, PL	None	Initially IV  steroids (stopped  ∼10 mo),  continues on  low dose oral  steroids	Initially IV CPH  and steroids  (stopped ∼4  yr), continues  on PL	Initially IV  steroids  (stopped ∼5  yr), continues  on PL	Initially IV  steroids  (stopped ∼3  yr), continues  on PL
Hematology	L, A, T	Normal	A	Normal	L, A	Normal	Normal	Normal	Normal
CD19⁺ cells  ×10³/ml		284		245		168	378	145	210
Renal	Abnormal	Normal	Abnormal	Normal	Borderline	Normal	Normal	Normal	Normal
ANA	+	+	+	+	+	+	NA	NA	NA
Serology	D, P, Sm,  RNP	Normal	P	Normal	D	Borderline D	D	Normal	Borderline D
ESR, mm/hr	11	25	>120	11	NA	41	50	10	12
Complement	Low	Normal	Low	Normal	Low	Normal	Normal	Normal	Normal

A, anemia; CPH, cyclophosphamide; D, anti–double-stranded DNA antibody; ESR, erythrocyte sedimentation rate; L, lymphopenia; MMF, mycophenolatemofetil; NA, not available; P, antiphospholipid antibody; PL, Plaquenil; RNP, anti-RNP antibody; Sm, anti-Smith antibody; T, thrombocytopenia.

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