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Table I.

Patient characteristics

Patient
SLE100
SLE101
SLE122
SLE14
SLE21
SLE33
Gender Female  Male  Female  Female Female Female 
Age at
 diagnosis 15 yr  15 yr  9 yr  11 yr 17 yr 7 yr 
Date
 of diagnosis 10/2002
 
 10/2002
 
 2/2003
 
 11/1998 10/1999 7/2001 
Sample SLE100 SLE100CR SLE101 SLE101CR SLE122 SLE122CR SLE14CR SLE21CR SLE33CR 
Sample date 10/10/2002 2/12/2004 10/24/2002 3/3/2004 2/22/2003 9/14/2004 6/1/2005 7/21/2005 8/8/2005 
Clinical
 course Arthritis,
 nephritis IIB Clinical
 remission Myocarditis,
 nephritis III Clinical
 remission Chorea,
 nephritis
 IIB Clinical
 remission Clinical
 remission Clinical
 remission Clinical
 remission 
Therapy None Initially IV steroids
 (stopped ∼3 mo),
 continues on low
 dose oral steroids,
 PL, aspirin None Initially IV
 steroids, CPH
 (stopped ∼10
 mo), continues
 on IV steroids,
 MMF, PL None Initially IV
 steroids (stopped
 ∼10 mo),
 continues on
 low dose oral
 steroids Initially IV CPH
 and steroids
 (stopped ∼4
 yr), continues
 on PL Initially IV
 steroids
 (stopped ∼5
 yr), continues
 on PL Initially IV
 steroids
 (stopped ∼3
 yr), continues
 on PL 
Hematology L, A, T Normal Normal L, A Normal Normal Normal Normal 
CD19+ cells
 ×103/ml  284  245  168 378 145 210 
Renal Abnormal Normal Abnormal Normal Borderline Normal Normal Normal Normal 
ANA NA NA NA 
Serology D, P, Sm,
 RNP Normal Normal Borderline D Normal Borderline D 
ESR, mm/hr 11 25 >120 11 NA 41 50 10 12 
Complement Low Normal Low Normal Low Normal Normal Normal Normal 
Patient
SLE100
SLE101
SLE122
SLE14
SLE21
SLE33
Gender Female  Male  Female  Female Female Female 
Age at
 diagnosis 15 yr  15 yr  9 yr  11 yr 17 yr 7 yr 
Date
 of diagnosis 10/2002
 
 10/2002
 
 2/2003
 
 11/1998 10/1999 7/2001 
Sample SLE100 SLE100CR SLE101 SLE101CR SLE122 SLE122CR SLE14CR SLE21CR SLE33CR 
Sample date 10/10/2002 2/12/2004 10/24/2002 3/3/2004 2/22/2003 9/14/2004 6/1/2005 7/21/2005 8/8/2005 
Clinical
 course Arthritis,
 nephritis IIB Clinical
 remission Myocarditis,
 nephritis III Clinical
 remission Chorea,
 nephritis
 IIB Clinical
 remission Clinical
 remission Clinical
 remission Clinical
 remission 
Therapy None Initially IV steroids
 (stopped ∼3 mo),
 continues on low
 dose oral steroids,
 PL, aspirin None Initially IV
 steroids, CPH
 (stopped ∼10
 mo), continues
 on IV steroids,
 MMF, PL None Initially IV
 steroids (stopped
 ∼10 mo),
 continues on
 low dose oral
 steroids Initially IV CPH
 and steroids
 (stopped ∼4
 yr), continues
 on PL Initially IV
 steroids
 (stopped ∼5
 yr), continues
 on PL Initially IV
 steroids
 (stopped ∼3
 yr), continues
 on PL 
Hematology L, A, T Normal Normal L, A Normal Normal Normal Normal 
CD19+ cells
 ×103/ml  284  245  168 378 145 210 
Renal Abnormal Normal Abnormal Normal Borderline Normal Normal Normal Normal 
ANA NA NA NA 
Serology D, P, Sm,
 RNP Normal Normal Borderline D Normal Borderline D 
ESR, mm/hr 11 25 >120 11 NA 41 50 10 12 
Complement Low Normal Low Normal Low Normal Normal Normal Normal 

A, anemia; CPH, cyclophosphamide; D, anti–double-stranded DNA antibody; ESR, erythrocyte sedimentation rate; L, lymphopenia; MMF, mycophenolatemofetil; NA, not available; P, antiphospholipid antibody; PL, Plaquenil; RNP, anti-RNP antibody; Sm, anti-Smith antibody; T, thrombocytopenia.

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