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Table I.

Baseline characteristics of stage 1 patients according to clinical status


HC
MSM
SM
Number 48 48 51 
Age (y):
     mean (range) 27 (18–42) 28 (18–56) 29 (18–56) 
Males:
     no. (%) 31 (65) 32 (67) 37 (72) 
Weight (kg):
     mean (range) 59 (42–73) 58 (43–77) 57 (45–85) 
Ethnicity:
     no. (%) Papuan highlander* 42 (87) 37 (77) 27 (53) 
Current smoker:
     no. (%) 23 (48) 19 (40) 22 (43) 
Exsmoker:
     no. (%)* 3 (6) 7 (14) 8 (15) 
Days of fever before presentation:
     median (IQR)‡ NA 2 (1-5) 4 (1-7) 
Systolic blood pressure (mmHg):
     mean (range)‡ 130 (96–136) 114 (88–152) 106 (60–154) 
Hypertensive on enrollment (%) 
Pulse rate (beats/min):
     mean (range)‡ 68 (44–104) 86 (56–118) 97 (61–138) 
Respiratory rate (breaths/min):
     mean (range)‡ 20 (18–26) 25 (14–42) 30 (16–60) 
Temperature (°C):
     mean (range)‡ 35.6 (35–36.7) 36.5 (34.1–39.8) 37.1 (34.8–40.3) 
Coma:
     no. (%)* 28 (55) 
Time (h) from start of antimalarial
     therapy to physiological testing:
     mean (95% CI)‡ NA 4.5 (3–6) 8 (6–10) 

HC
MSM
SM
Number 48 48 51 
Age (y):
     mean (range) 27 (18–42) 28 (18–56) 29 (18–56) 
Males:
     no. (%) 31 (65) 32 (67) 37 (72) 
Weight (kg):
     mean (range) 59 (42–73) 58 (43–77) 57 (45–85) 
Ethnicity:
     no. (%) Papuan highlander* 42 (87) 37 (77) 27 (53) 
Current smoker:
     no. (%) 23 (48) 19 (40) 22 (43) 
Exsmoker:
     no. (%)* 3 (6) 7 (14) 8 (15) 
Days of fever before presentation:
     median (IQR)‡ NA 2 (1-5) 4 (1-7) 
Systolic blood pressure (mmHg):
     mean (range)‡ 130 (96–136) 114 (88–152) 106 (60–154) 
Hypertensive on enrollment (%) 
Pulse rate (beats/min):
     mean (range)‡ 68 (44–104) 86 (56–118) 97 (61–138) 
Respiratory rate (breaths/min):
     mean (range)‡ 20 (18–26) 25 (14–42) 30 (16–60) 
Temperature (°C):
     mean (range)‡ 35.6 (35–36.7) 36.5 (34.1–39.8) 37.1 (34.8–40.3) 
Coma:
     no. (%)* 28 (55) 
Time (h) from start of antimalarial
     therapy to physiological testing:
     mean (95% CI)‡ NA 4.5 (3–6) 8 (6–10) 

*, P < 0.01, calculated from a χ2 test comparing SM, MSM (stage 1), and HC. ‡, P < 0.01, calculated from ANOVA comparing SM, MSM (stage 1), and HC; or where no data in HC, calculated from a two-sided t test comparing SM and MSM (stage 1). IQR, interquartile range; NA, not applicable.

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